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TranscriptomicsTranscription profiling of Streptomyces coelicolor wild type and delta0877 and delta7173 mutant strains
Gene expression analysis of S. coelicolor M145 wild type strain, and mutants delta0877 and delta 7173. RNA samples were extracted from 48 h culture samples during growth in flasks in defined mineral medium MG supplemented with 5% of yeast extract. Cy5 labelled genomic DNA was used as the common ref...
ORGANISM(S): Streptomyces coelicolor 
2009-04-17 | E-MEXP-2132 | biostudies-arrayexpress
Transcriptomicsshort and long attack latency mice
Two wild house mice lines were genetically selected for short and long attack latency. Mice with an attack latency <50s or >600s were considered short attack latency mice (SAL) and long attack latency mice(LAL) respectively. RNA from the hippocampus of 14 SAL or 14 LAL mice was pooled and used as in...
ORGANISM(S): Mus musculus 
2003-10-30 | E-GEOD-786 | biostudies-arrayexpress
ProteomicsFrom LAL-D to MASLD: Insights into the role of LAL and Kupffer cells in liver inflammation and lipid metabolism
Metabolic dysfunction-associated steatotic liver disease (MASLD) is a prevalent liver pathology worldwide, closely associated with obesity and metabolic disorders. Increasing evidence suggests that macrophages play a crucial role in the development of MASLD. Several human studies have shown an inver...
ORGANISM(S): Mus musculus (Mouse) 
2024-12-01 | PXD056343 | Pride
Mouse Timstof pro 2 
ProteomicsComparative gene expression profiling of mutants of Amycolatopsis mediterranei S699
The project aims to unveil the mechanism of rifamycin and its analog production by wild type A. mediterranei S699 and mutant A. mediterranei DCO#34 known to produce 24-desmethylrifamycin B at two time points. Stain that donot produce this molecule is taken as the negative control in the study.
ORGANISM(S): Amycolatopsis mediterranei S699 
2021-03-11 | PXD016416 | Pride
24-desmethylrifamycin b Amycolatopsis 42h and 96h Production mechanism Rifamycin 
UnknownFrom LAL-D to MASLD: Insights into the role of LAL and Kupffer cells in liver inflammation and lipid metabolism.
Not available
S-EPMC7618626 | biostudies-literature
UnknownImpact of (intestinal) LAL deficiency on lipid metabolism and macrophage infiltration.
Not available
S-EPMC10209539 | biostudies-literature
UnknownLAL regulators SCO0877 and SCO7173 as pleiotropic modulators of phosphate starvation response and actinorhodin biosynthesis in Streptomyces coelicolor.
Not available
S-EPMC3282765 | biostudies-literature
ProteomicsLoss of lysosomal acid lipase results in mitochondrial dysfunction and fiber switch in skeletal muscles of mice
Objective: Lysosomal acid lipase (LAL) is the only enzyme known to hydrolyze cholesteryl esters (CE) and triacylglycerols in lysosomes at an acidic pH. Despite the importance of lysosomal hydrolysis in skeletal muscle (SM), research in this area is limited. We hypothesized that LAL may play an impor...
ORGANISM(S): Mus musculus (Mouse) 
2024-01-26 | PXD045665 | Pride
Muscle proteomics Lal Lal deficiency Energy metabolism Lal-deficient mouse 
ProteomicsLanifibranor reduces inflammation and improves dyslipidemia in lysosomal acid lipase-deficient mice
Background & Aims Recent studies showed that patients suffering from lysosomal acid lipase-deficiency (LAL-D) benefit tremendously from enzyme replacement therapy (ERT), however, the outcomes on liver histology in treated patients were inconsistent. The promising results of the pan-PPAR agonist lani...
ORGANISM(S): Mus musculus (Mouse) 
2024-06-12 | PXD047957 | Pride
Pan-ppar agonist Proteomics Lipid metabolism Lysosomal acid lipase deficiency Liver inflammation Plasma lipoproteins Lanifibranor 
UnknownLoss of function of lysosomal acid lipase (LAL) profoundly impacts osteoblastogenesis and increases fracture risk in humans.
Not available
S-EPMC8108562 | biostudies-literature
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