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TranscriptomicsTranscription profiling of human CD4+ leukemia Jurkat T-cells in which the PI3K pathway is constitutively turned-on and FOXO1 transcriptional activity strongly repressed
One major effect of PI3-kinase activation downstream of the serine/threonine kinase Akt is the phosphorylation of the transcription factor FOXO1 and its neutralization. FOXO1 has several ubiquitous targets genes in many cell types that control cell quiescence, oxydative stress or apoptosis. However,...
ORGANISM(S): Homo sapiens 
2008-12-01 | E-TABM-391 | biostudies-arrayexpress
TranscriptomicsMolecular profiling of hypothalamic leucine-sensing neurons via PhosphoTRAP
To identify the molecular signature of leucine-activated neurons in the MBH, we adopted the PhosphoTRAP assay following parenchymal injection of leucine into the MBH. Neurons activated following MBH leucine injection (and expressing the neuronal activation marker cFos) co-express Ser240/244-phospho...
ORGANISM(S): Mus musculus 
2026-04-01 | E-MTAB-16665 | biostudies-arrayexpress
TranscriptomicsComparison of gene expression profile of human trabecular meshwork cells induced by triamcinolone with dexamethasone
PURPOSE. Triamcinolone acetonide (TA) and dexamethasone (DEX) are corticosteroids commonly used for ocular inflammation but both can cause ocular hypertension. We investigated the differential gene expression profile of human trabecular meshwork (TM) cells in response to treatment by TA compared to ...
ORGANISM(S): Homo sapiens 
2008-05-01 | E-GEOD-6298 | biostudies-arrayexpress
ProteomicsEffects of age and sex on protein abundance in the mouse heart
We compared protein abundance in the left and right ventricles of male and female C57BL6/J mice at 4 months and 20 months old. Frozen tissues were weighed, thawed, and cut into small pieces (2-3 mm3) on weigh boats on ice. Tissue pieces were transferred to 2.0 mL eppendorf tubes. Cold RIPA (Thermo #...
ORGANISM(S): Mus Musculus (mouse) 
2022-11-08 | PXD033719 | JPOST Repository
TranscriptomicsTranscription profiling of Drosophila melanogaster third instar larvae organ cultures treated with 20-hydroxyecdysone, cycloheximide vs controlds to identify 20-hydroxyecdysone regulated genes at the onset of metamorphosis
To identify 20E-regulated genes, wandering third instar larvae were dissected and their organs were cultured in the presence of either no hormone, 20E alone, cycloheximide alone, or 20E plus cycloheximide for six hours. Experiment Overall Design: Eight partial blue gut third instar larvae were disse...
ORGANISM(S): Drosophila melanogaster 
2007-10-31 | E-GEOD-3060 | biostudies-arrayexpress
TranscriptomicsModeling host-microbe interactions in immunocompetent engineered human gut tissues
This data provides a single-cell RNA-seq characterization of human intestinal engineered epithelium and its interaction with tissue-resident memory T cells (scRNA-seq) or the pathogen Salmonella Typhimurium (scRNA-seq and scATAC-seq).
ORGANISM(S): Homo sapiens 
2026-08-17 | E-MTAB-16821 | biostudies-arrayexpress
GenomicsIntegrated approaches reveal determinants of genome-wide binding and function of the transcription factor Pho4
Binding of transcription factors to DNA is a key regulatory step in the control of gene expression. DNA sequences with high affinity for transcription factors occur more frequently in the genome than instances of genes bound or regulated by these factors. Although several mechanisms have been iden...
ORGANISM(S): Saccharomyces cerevisiae 
2011-09-27 | E-GEOD-29506 | biostudies-arrayexpress
TranscriptomicsInfluence of BrpA on critical virulence attributes of Streptococcus mutans
Streptococcus mutans, the primary etiological agent of human dental caries, has developed multiple mechanisms to colonize and form biofilms on the tooth surface. The brpA gene codes for a predicted surface-associated protein with apparent roles in biofilm formation, autolysis, and cell division. In ...
ORGANISM(S): Streptococcus mutans 
2008-08-30 | E-GEOD-11773 | biostudies-arrayexpress
TranscriptomicsTranscriptome changes in leaves of the DEFENSE NO DEATH 1 (DND1) silenced potato plants
Silencing of DND1 in potato leads to resistance to late blight, powdery mildew and Botrytis cinerea. At the same time, however, it reduces plant growth and causes leaf necrosis. To get knowledge on the molecular events behind the pleiotropic effect of DND1 downregulation in potato transcriptome anal...
ORGANISM(S): Solanum tuberosum 
2024-10-22 | E-MTAB-13824 | biostudies-arrayexpress
TranscriptomicsGene Expression data of P4 stage hair follicle ORS cells from DTG (K14-rtTA,TRE-miR-125b) and control littermates
Increasing evidence suggests that microRNAs may play important roles in regulating self-renewal and differentiation in mammalian stem cells (SCs). Here, we explore this issue in skin. We first characterize microRNA expression profiles of skin SCs versus their committed proliferative progenies and id...
ORGANISM(S): Mus musculus 
2011-01-04 | E-GEOD-26394 | biostudies-arrayexpress
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