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TranscriptomicsEYA4 is a non-small cell lung cancer tumor suppressor located in the susceptibility locus on chromosome 6q
This study was undertaken to identify novel tumour suppressor genes in lung adenocarcinoma. EYA4, located at 6q23.2 was identified as a frequently lost and hypermethylated gene in the analyzed samples. EYA4 is underexpressed in addition to being deleted and hypermethylated. Control of EYA4 expres...
ORGANISM(S): Homo sapiens 
2014-02-25 | E-GEOD-19034 | biostudies-arrayexpress
ProteomicsSex differences in the ventral tegmental area and nucleus accumbens proteome at baseline and following nicotine exposure
Sex differences in behaviors relevant to nicotine addiction have been observed in rodent models and human subjects. Behavioral, imaging and epidemiological studies also suggest underlying sex differences in mesolimbic dopamine signaling pathways. In this study we evaluated the proteome in the ventra...
ORGANISM(S): Mus musculus (Mouse) 
2021-06-28 | PXD023859 | Pride
Sex Nicotine exposure Mouse Vta Nac 
TranscriptomicsRNA sequencing of sperm extracted from the epididymis in naked mole-rat subordinates, naked mole-rat ex-subordinates, and mice
Naked mole-rat show a strong phenotype of sperm hypo-motility and abnormal morphology. Comparative genomic analyses in our study presenting the telomere-to-telomere genome for the naked mole-rat identified several sperm-gene relaxation and sperm-gene loss events in the NMR. To test the transcriptomi...
ORGANISM(S): Mus musculus 
2026-07-31 | E-MTAB-17270 | biostudies-arrayexpress
GenomicsONT R10.4-Lsk sequencing of a naked mole-rat male subordinate. Sheared kidney, unsheared kidney, and brain samples
Two PacBio Hifi sequencing runs from the kidney of a single male NMR sample used to make the mHetGla4.1.primary genome assembly. Specifically, we assembled a second NMR genome from an unrelated male of a separate captive colony in Toronto, Canada, using PacBio HiFi (155.8 Gb, read N50 = 11.45 Kb) an...
ORGANISM(S): Heterocephalus glaber 
2026-08-06 | E-MTAB-17334 | biostudies-arrayexpress
UnknownEffect of age on chronic inflammation and responsiveness to bacterial and viral challenges.
Not available
S-EPMC5706672 | biostudies-literature
GenomicsEpiChip: Gene-by-gene quantification of epigenetic modification levels
Using datasets for the H3KAc histone modification in Th2 cells and an accompanying IgG control, we present an analysis strategy termed 'EpiChip' that alternates between single gene and global data distribution levels and allows a clear distinction between experimental background and signal. Examinat...
ORGANISM(S): Mus musculus 
2010-12-07 | E-GEOD-23092 | biostudies-arrayexpress
UnknownA globally synthesised and flagged bee occurrence dataset and cleaning workflow.
Not available
S-EPMC10622554 | biostudies-literature
ProteomicsCocaine self-administration induces divergent protein expression in the nucleus accumbens of male and female mice to eliminate basal sex differences
Substance use disorder (SUD) is a chronic neuropsychiatric condition characterized by long-lasting alterations in the neural circuitry regulating reward and motivation. Substantial work has focused on characterizing the molecular substrates which underlie these persistent changes in neural function ...
ORGANISM(S): Mus musculus (Mouse) 
2021-09-09 | PXD022832 | Pride
Mus musculus Mouse Nucleus accumbens Cocaine 
TranscriptomicsIdentifying transcription start sites and active enhancer elements using BruUV-seq
BruUV-seq utilizes UV light to introduce transcription-blocking DNA lesions randomly in the genome prior to bromouridine-labeling and deep sequencing of nascent RNA. By inhibiting transcription elongation, but not initiation, pre-treatment with UV light leads to a redistribution of transcription rea...
ORGANISM(S): Homo sapiens 
2015-12-21 | E-GEOD-75398 | biostudies-arrayexpress
GenomicsNaked mole rat hypothalamus chromatin state map
The naked mole-rat (NMR; Heterocephalus glaber) is a eusocial subterranean rodent with a highly unusual set of physiological traits, such as extreme longevity, that has attracted great interest amongst the scientific community. However, the genetic basis of most of these traits has not been elucidat...
ORGANISM(S): Heterocephalus glaber 
2025-11-22 | E-MTAB-14648 | biostudies-arrayexpress
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