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ProteomicsElp2 mutations perturb the epitranscriptome and lead to a complex neurodevelopmental phenotype
Neurodevelopmental disorders have a variety of aetiologies and most often these are complex genomic traits involving numerous mutations. Intellectual disability (ID) and autism spectrum disorder (ASD) are the most common neurodevelopmental disorders and are characterized by substantial impairment in...
ORGANISM(S): Mus musculus (Mouse) 
2021-01-19 | PXD023653 | Pride
Trna modifications Mouse Brain cortex Elongator complex Epitranscriptome Autism Intellectual disability Elp2 
UnknownA cost-effective alkaline polysulfide-air redox flow battery enabled by a dual-membrane cell architecture.
Not available
S-EPMC9061742 | biostudies-literature
GenomicsMethylation Changes During Soybean Seed Development
What methylation changes are occurring during seed development largely remains unknown. To uncover the possible role of DNA methylation during the transition from seed differentiation to maturation and dormany in soybean, we characterized the methylome of whole seeds representing the differentiation...
ORGANISM(S): Glycine max 
2011-12-22 | E-GEOD-34637 | biostudies-arrayexpress
ProteomicsIdentification of proteins bound with RPA194 at rRNA loci in primary versus metastatic breast cancer cells
The nucleolus, the site of ribosome biogenesis, serves as a central hub for sensing and responding to cellular stress and plays a crucial role in this process; furthermore, emerging evidence highlights the potential role of ribosome biogenesis in driving metastasis. A combined approach of chromatin ...
ORGANISM(S): Homo sapiens (Human) 
2025-07-27 | PXD060651 | Pride
Breast cancer Rpa194 Chip Metastasis 
TranscriptomicsGenome-Wide Small RNA Profiling of a Soybean Seed Compartment
We report the genome-wide small RNA of soybean early maturation seed coat parenchyma compartment soybean early maturation seeds using Illumina high-throughput sequencing technology. Illumina sequencing of small RNA from early maturation seed coat parenchyma compartment and early-maturation stage who...
ORGANISM(S): Glycine max 
2011-12-22 | E-GEOD-34638 | biostudies-arrayexpress
GenomicsMethylation Changes in Soybean Early Maturation Seed Parts
What methylation changes are occurring in different parts of early maturation stage seed largely remains unknown. To uncover the possible role of DNA methylation in different parts of early maturation stage seed, we characterized the methylome of seed coats,cotyledons, and the embryonic seed axis us...
ORGANISM(S): Glycine max 
2012-05-11 | E-GEOD-37895 | biostudies-arrayexpress
TranscriptomicsTranscript Profiling of Soybean Seed Compartments Using Laser Capture Microdissection Coupled With RNA-Seq
We used laser capture microdissection (LCM) to capture soybean seed compartments and profiled the transcriptomes of several compartments using next-generation sequencing. We profiled the transcriptomes of the embryo-proper and the suspensor region from globular stage embryos and the seed coat paren...
ORGANISM(S): Glycine max 
2011-05-10 | E-GEOD-29162 | biostudies-arrayexpress
ProteomicsDifferential analysis of nucleolar proteomics in metastatic breast cancer
The nucleolus, responsible for ribosome biogenesis, acts as a key center for detecting and responding to cellular stress. Additionally, growing evidence suggests that ribosome biogenesis may play a significant role in promoting metastasis. A proteomic screen of nucleolar protein content between meta...
ORGANISM(S): Homo sapiens (Human) 
2025-07-27 | PXD060687 | Pride
Nucleolus Breast cancer Metastasis 
TranscriptomicsEpigenetic Regulation of the Transition from Seed Maturation to Germination in Soybean
How epigenetics is involved in the transition from seed maturation to seed germination largely remains elusive. To uncover the possible role of epigenetics in gene expression during the transition from seed maturation to seed germination in soybean, the transcriptome of cotyledons from four stages o...
ORGANISM(S): Glycine max 
2011-05-10 | E-GEOD-29134 | biostudies-arrayexpress
MetabolomicsMetabolic phenotyping of urine from a dementia research cohort
To better understand the molecular mechanisms underpinning physiological variation in human populations, metabolic phenotyping approaches are increasingly being applied to studies involving hundreds and thousands of biofluid samples. Hyphenated ultra-performance liquid chromatography-mass spectromet...
2022-03-01 | MTBLS719 | MetaboLights
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