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ProteomicsMolecular markers in the CSF proteome differentiate neuroinflammatory diseases
Manuscript "Molecular markers in the CSF proteome differentiate neuroinflammatory diseases" by Maria L. Elkjaer Arkadiusz Nawrocki, Tim Kacprowski, Anja Hviid Simonsen, Romain Marignier, Tobias Sejbaek, Helle H. Nielsen, Lene Wermuth, Peter Høgh, Finn Sellebjerg, Richard Reynolds, Jan Baumbach, Mart...
ORGANISM(S): Homo sapiens (Human) 
2021-02-22 | PXD017643 | Pride
Human csf Multiple sclerosis Proteomics 
ProteomicsMolecular markers in the CSF proteome differentiate neuroinflammatory diseases
Manuscript "Molecular markers in the CSF proteome differentiate neuroinflammatory diseases" by Maria L. Elkjaer Arkadiusz Nawrocki, Tim Kacprowski, Anja Hviid Simonsen, Romain Marignier, Tobias Sejbaek, Helle H. Nielsen, Lene Wermuth, Peter Høgh, Finn Sellebjerg, Richard Reynolds, Jan Baumbach, Mart...
ORGANISM(S): Homo sapiens (Human) 
2022-08-08 | PXD017681 | Pride
Human csf Multiple sclerosis Proteomics 
ProteomicsEnrichment of Cysteine S-palmitoylated peptides using Sodium Deoxycholate Acid Precipitation - SDC-ACE
S-palmitoylation is a poorly understood post-translational modification that is gaining more attention as an essential regulator of cellular processes. The reversible nature of S-palmitoylation allows for fine-tuned control of cellular events and adaptation to stimuli. The enrichment of S-palmitoyla...
ORGANISM(S): Mus musculus (Mouse) Acyrthosiphon pisum (Pea aphid) 
2026-02-16 | PXD054682 | Pride
Cysteine palmitoylation  mouse brain palmitoylome  dbdb mice  mouse tissue specific palmitoylation 
ProteomicsPharmacological inhibition of mitochondrial soluble adenylyl cyclase in astrocytes causes activation of AMP-activated protein kinase and induces breakdown of glycogen
Astrocytes contain the majority of the brain’s supply of glycogen which has been suggested to play an important role in neuronal synaptic plasticity. This may be mediated by release of glycogen-derived lactate or glutamine supporting neuronal metabolism or via induction of neuronal signaling pathway...
ORGANISM(S): Mus musculus (Mouse) Acyrthosiphon pisum (Pea aphid) 
2021-08-13 | PXD027901 | Pride
Mouse astrocytes Amp-activated protein kinase Energy metabolism Adenylyl cyclase Phosphorylation 
ProteomicsBeta cell dysfunction and dedifferentiation induced by Bone Morphogenetic Protein (BMP)-2 is associated with histone modifications and decreased NeuroD1 chromatin binding
Insufficient insulin secretion is a hallmark of type 2 diabetes and has been attributed to beta cell identity loss characterized by a decreased expression of several key beta cell genes. The pro-inflammatory factor BMP-2 is upregulated in islets of Langerhans from diabetic individuals and acts as an...
ORGANISM(S): Mus musculus (Mouse) 
2023-07-20 | PXD036655 | Pride
Rna Histone Bmp-2 Proteomics 
ProteomicsSpatial and temporal effects in protein post-translational modification distributions in the developing mouse brain
Protein post-translational modification (PTM) is a powerful way to modify the behavior of cellular proteins and thereby cellular behavior. Multiple recent studies of evolutionary trends have shown that certain pairs of protein post-translational modifications tend to occur closer to each other than ...
ORGANISM(S): Mus musculus (Mouse) 
2016-04-11 | PXD003932 | Pride
Development Post-translational modifications Mouse brain 
ProteomicsSsimultaneous enrichment of cysteine-containing peptides and phosphopeptides using a novel Cysteine-specific Phosphonate Adaptable Tag (CysPAT) in combination with TiO2 chromatography
Cysteine is a rare and conserved amino acid involved in most cellular functions. The thiol group of cysteine can be subjected to diverse oxidative modifications that regulate most physio-pathological states. Here, a Cysteine-specific Phosphonate Adaptable Tag (CysPAT) was synthesized to selectively ...
ORGANISM(S): Homo sapiens (Human) 
2016-06-13 | PXD002704 | Pride
Cyspat  reversible cys modifications  redox chemistry  protein phosphorylation  tio2 enrichment  cross-talk  proteomics 
MetabolomicsEvaluation of sample preparation methods for NMR-based metabolomics of cow milk
The quality of milk metabolome analyzed by nuclear magnetic resonance (NMR) is greatly influenced by the way samples are prepared. Although this analytical method is increasingly used to study milk metabolites, a thorough examination of available sample preparation protocols for milk has not been re...
2019-06-13 | MTBLS623 | MetaboLights
ProteomicsSynaptic transmission induces site specific changes in sialylation on N-linked glycoproteins in nerve terminals
Synaptic transmission is an ultra-fast process that aims at transducing a signal from one neuron to another neuron or cell by the release of neurotransmitters. This process requires rapid response which can be transmitted through fast molecular switches such as post-translational modifications of pr...
ORGANISM(S): Rattus norvegicus (Rat) 
2020-06-12 | PXD016230 | Pride
Synaptic transmission Sialic acid N-glycosylation Rat Synaptosomes Lc-ms/ms 
ProteomicsDynamic changes in the protein localization in the nuclear environment in pancreatic β-cell after brief glucose stimulation
We focus on the characterization of proteins in the nuclear environment of β-cells after brief, high glucose-stimulation. We compared purified nuclei derived from β-cells stimulated with 17mM glucose for 0, 2, and 5 minutes using quantitative proteomics, a time frame that most likely does not result...
ORGANISM(S): Mus musculus (Mouse) Rattus norvegicus (Rat) 
2018-03-12 | PXD008988 | Pride
Lc-msms Pancreatic beta-cells Gsis Nucleus 
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