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GenomicsLoss of 5-hydroxymethylcytosine is an epigenetic hallmark of melanoma
DNA methylation at the 5-position of cytosine (5-mC) is a key epigenetic mark critical for varius biological and pathological processes. 5-mC can be converted to 5-hydroxymethylcytosine (5-hmC) by the Ten-Eleven Translocation (TET) family of DNA hydroxylases. Here we report that "loss of 5-hmC&...
ORGANISM(S): Homo sapiens 
2012-09-18 | E-GEOD-38231 | biostudies-arrayexpress
TranscriptomicsTemperature-dependent transcriptional response under anaerobic C and N limitations in Yeast
The global transcriptional response of Saccharomyces cerevisiae was investigated in low temperature chemostat cultures grown in carbon or nitrogen limitation. During steady state chemostats, the growth rates and in vivo fluxes were kept constant however the growth-limiting nutrient was significantly...
ORGANISM(S): Saccharomyces cerevisiae 
2007-01-20 | E-GEOD-6190 | biostudies-arrayexpress
MetabolomicsEvidence for quorum sensing and differential metabolite production by Ruegeria pomeroyi in response to DMSP
Microbial alteration and remineralization of organic matter in the ocean play essential roles in the carbon cycle. The impact of individual compounds as either growth substrates or infochemicals is still poorly constrained in models, particularly for organisms with relatively versatile genomes. Here...
2015-01-29 | MTBLS157 | MetaboLights
TranscriptomicsTranscriptional responses of yeast to preferred and non-preferred nitrogen sources in C-lim chemostat cultures
Aerobic, glucose-limited chemostat cultures of Saccharomyces cerevisiae grown with six different nitrogen sources were subjected to transcriptome analysis. The use of chemostats enabled an analysis of nitrogen-source-dependent transcriptional regulation at a fixed specific growth rate. A selection o...
ORGANISM(S): Saccharomyces cerevisiae 
2007-02-28 | E-GEOD-6405 | biostudies-arrayexpress
UnknownTensor image enhancement and optimal multichannel receiver combination analyses for human hyperpolarized 13 C MRSI.
Not available
S-EPMC7718428 | biostudies-literature
GenomicsDNA-seq of an ELMSeq reporter cassette to study impact of C-terminal sequence variations on protein abundance
A ELMSeq reporter cassette was created to monitor Dam levels by methylation, and introduced in the genome. The regions of 6 nt upstream and 6 nt downstream the stop codon were randomized to study their effect on gene expression. The ELMSeq reporter cassette was composed of: promoter - dam - random N...
ORGANISM(S): Mycoplasma pneumoniae 
2020-05-04 | E-MTAB-8223 | biostudies-arrayexpress
MetabolomicsA Phosphate starvation response gene (psr1-like) is present in Micromonas pusilla and other marine algae and coordinates the metabolic response to phosphate deficiency
Both marine phytoplankton and terrestrial plants have to deal with limited bioavailability of the key life nutrient, phosphate. In freshwater algae and plants, a phosphate starvation response gene (psr1) has been characterized, which encodes for a transcription factor that regulates the metabolic re...
2016-02-01 | MTBLS295 | MetaboLights
MetabolomicsRegulatory T cells promote endurance exercise adaptation by shielding muscle mitochondria from damage

Exercise enhances physical performance and reduces the risk of many disorders such as cardiovascular disease, type 2 diabetes, dementia and cancer. Exercise characteristically incites an inflammatory response, notably in skeletal muscles. While some effector mechanisms have been identified, regul...

2023-10-10 | MTBLS8391 | MetaboLights
MetabolomicsRelease of Ecologically Relevant Metabolites by the Cyanobacterium, Synechococcus elongatus CCMP 1631
Phytoplankton are known to release organic compounds that fuel secondary production by heterotrophic bacteria. Here we show that an abundant marine cyanobacterium, Synechococcus elongatus, contributes a variety of nitrogen-rich and sulfur-containing compounds to dissolved organic matter. A combinati...
2015-01-26 | MTBLS155 | MetaboLights
MetabolomicsIntracellular metabolites from an experimental manipulation of marine microorganisms
The marine environment holds one of the largest pools of reduced organic carbon on Earth. Within this organic carbon are metabolites produced as a result of microbial activity. This project considers the effects of predation and viral lysis on the metabolites found in the surface ocean. Using seawat...
2017-05-23 | MTBLS461 | MetaboLights
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