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MetabolomicsMass spectrometry based metabolomics for in vitro systems pharmacology: Pitfalls, challenges, and computational solutions

INTRODUCTION: Mass spectrometry based metabolomics has become a promising complement and alternative to transcriptomics and proteomics in many fields including in vitro systems pharmacology. Despite several merits, metabolomics based on liquid chromatography mass spectrometry (LC...

2017-08-23 | MTBLS401 | MetaboLights
MetabolomicsIntegration of magnetic resonance imaging and protein and metabolite CSF measurements to enable early diagnosis of secondary progressive multiple sclerosis

Molecular networks in neurological diseases are complex. Despite this fact, contemporary biomarkers are in most cases interpreted in isolation, leading to a significant loss of information and power. We present an analytical approach to scrutinize and combine information from biomarkers originati...

2018-08-13 | MTBLS558 | MetaboLights
ProteomicsInhibition of mPGES-1 or COX-2 Results in Different Proteomic and Lipidomic Profiles in A549 Lung Cancer Cells
We compared the effects of mPGES-1 inhibitor Compound III (CIII) with the cyclooxygenase (COX)-2 inhibitor NS-398 on protein and lipid profiles in interleukin (IL)-1β induced A549 lung cancer cells using mass spectrometry. Inhibition of mPGES-1 decreased PGE2 production and increased PGF2α and throm...
ORGANISM(S): Homo sapiens (Human) 
2019-05-20 | PXD013490 | Pride
Inflammation A549 Cancer Mpges-1 Lc-ms/ms 
MetabolomicsDisease phenotype prediction in multiple sclerosis

Progressive multiple sclerosis (PMS) is currently diagnosed retrospectively. Here, we work towards a set of biomarkers that could assist in early diagnosis of PMS. A selection of cerebrospinal fluid metabolites (n=15) was shown to differentiate between PMS and its preceding phenotype in an indepe...

2023-05-31 | MTBLS1464 | MetaboLights
UnknownKlotho controls the brain-immune system interface in the choroid plexus.
Not available
S-EPMC6275534 | biostudies-literature
ProteomicsProteomics on colorectal cancer MCTS upon OXPHOS inhibition
Previous high throughput gene expression profiling combined with a HCT116 colon cancer tumor spheroid-based drug-screening assay identified context-dependent treatment responses to OXPHOS inhibitors resulting in a shunting towards the mevalonate pathway. To complement these findings with a character...
ORGANISM(S): Homo sapiens (Human) 
2020-07-29 | PXD016495 | Pride
Colon cancer Oxphos Proteomics Spheroids Energy metabolism 
ProteomicsGlobal analysis of the human cytomegalovirus interactome identifies degradation hubs, domain associations and viral protein functions
Human cytomegalovirus (HCMV) is an important pathogen that extensively modulates host cells, downregulating >900 human proteins over the course of viral replication and degrading ≥133 proteins shortly after infection. The mechanism of degradation of most host proteins remains unresolved, and the fun...
ORGANISM(S): Human herpesvirus 5 strain Merlin Homo sapiens (Human) Betaherpesvirinae 
2020-01-22 | PXD014845 | Pride
Proteomics  systems virology  human cytomegalovirus  host-pathogen interaction  immune evasion  protein-protein interaction 
TranscriptomicsTargeting of Painting of fourth to roX1 and roX2 proximal sites suggests evolutionary links between dosage compensation and the regulation of the 4th chromosome in Drosophila melanogaster
In Drosophila melanogaster, two chromosome-specific targeting and regulatory systems have been described. The male-specific lethal (MSL) complex supports dosage compensation by stimulating gene expression from the male X-chromosome and the protein Painting of fourth (POF) specifically targets and st...
ORGANISM(S): Drosophila melanogaster 
2013-05-27 | E-GEOD-45402 | biostudies-arrayexpress
UnknownClimate change and sexual and reproductive health and rights research in low-income and middle-income countries: a scoping review.
Not available
S-EPMC11816306 | biostudies-literature
UnknownCoherent soft X-ray diffraction imaging of coliphage PR772 at the Linac coherent light source.
Not available
S-EPMC5501160 | biostudies-literature
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