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TranscriptomicsTranscription profiling of V. vinifera Cabernet sauvignon and V. aestivalis Norton innoculated with Erysiphe necator conidiospores
we analyzed pathogen-induced changes in the transcriptome of Vitis vinifera ‘Cabernet sauvignon’ and Vitis aestivalis ‘Norton’ by conducting a large-scale study to measure transcript abundance at 0, 4, 8, 12, 24, and 48 hours post-treatment in conidiospore- and mock-inoculated leaves using A...
ORGANISM(S): Vitis aestivalis 
2008-06-14 | E-GEOD-6404 | biostudies-arrayexpress
Proteomics17β-Estradiol Delivered in Eye Drops: A Proteomics Study Focusing on the Rat Retina
Five ovariectomized (OVX) Brown Norway rats (Charles Rivers Laboratories, Wilmington, DE, USA) weighing 200-250 g received 10 µL of 17β-estradiol (E2) eye drops once daily in both eyes for three weeks [20]. The eye drops contained 0.1% (w/v) E2 in saline vehicle containing 20% (w/v) 2-hydroxypropyl-...
ORGANISM(S): Rattus norvegicus (Rat) 
2020-05-27 | PXD010851 | Pride
Retina Datadependent acquisition Rat Label-free Estradiol 
ProteomicsProteomics-Based Retinal Target Engagement Analysis and Retina-Targeted Delivery of 17β-Estradiol by the DHED Prodrug in Males. Katalin Prokai-Tatrai,* Khadiza Zaman, Vien Nguyen, Daniel L. De La Cruz and Laszlo Prokai
We examined the impact of 17β-estradiol (E2) eye drops on the modulation of the proteome pro-file in the male rat retina. With discovery-driven proteomics, we have identified proteins that were regulated by the treatment. These proteins were assembled to several bioinformatics-based networks implica...
ORGANISM(S): Rattus norvegicus (Rat) 
2021-11-04 | PXD027902 | Pride
Prote-omics Isotope-dilution Targeted proteomics Dhed prodrug Neuroprotection  lc-ms/ms 17β-estradiol  e2  eye drops  male retina  parallel-reaction monitoring 
ProteomicsProteomics Complementation of the Rat Uterotrophic Assay for Estrogenic Endocrine Disruptors: A Roadmap of Advancing High Resolution Mass Spectrometry-based Shotgun Survey to Targeted Biomarker Quantifications Authors: Laszlo Prokai *, Fatima Rahlouni, Khadiza Zaman,Vien Nguyen, and Katalin Prokai-Tatrai
The widely used rat uterotrophic assay to assess known and potential estrogenic compounds only considers uterine weight gain as endpoint measurement. To complement this method with an advanced technology that reveals molecular targets, we analyzed changes in protein expression using label-free quant...
ORGANISM(S): Rattus norvegicus (Rat) 
2021-04-23 | PXD023273 | Pride
Strogen-regulated proteins  rat  uterus  liquid chromatography–mass spectrometry quantitative label-free proteomics  targeted pathway analysis  protein networks  endocrine disruption 
ProteomicsCytoplasmic complex comprising TAF2, TAF8, TAF10 provides evidence for nuclear holo-TFIID assembly from preformed submodules
General transcription factor TFIID is a cornerstone of RNA polymerase II transcription initiation in eukaryotic nuclei. Human TFIID is a megadalton-sized multiprotein complex composed of the TATA-binding protein (TBP) and 13 TBP-associated factors (TAFs). The cellular mechanism of TFIID assembly is ...
ORGANISM(S): Homo sapiens (Human) 
2016-06-15 | PXD001427 | Pride
Assembly Tfiid Tafstructure Mudpit analysis 
ProteomicsRetina-Targeted 17β-Estradiol by the DHED Prodrug Rescues Visual Function and Actuates Neuroprotective Protein Net-works after Optic Nerve Crush in a Rat Model of Surgical Menopause. Katalin Prokai-Tatrai, Khadiza Zaman, Ammar Kapic, Kelleigh Hogan , Gabriela Sanchez-Rodriguez, Anna E. Silverio Vien Nguyen , Laszlo Prokai and Andrew J. Feola
The association between 17β-estradiol (E2) deprivation, seen in menopause and a risk for devel-oping glaucoma, has been shown. Thus, exogenous supplementation of E2 may protect against retinal ganglion cell (RGC) degradation and vision loss. Here, we investigated the utility of topical 10β,17β-dihyd...
ORGANISM(S): Rattus norvegicus (Rat) 
2025-05-07 | PXD059520 | Pride
Bioinformatics  dhed  estrogen  glaucoma  menopause  optic nerve crush  optomotor response  protein–protein interaction networks  quantitative label-free retina proteomics 
ProteomicsIdentification of Proteins Significantly Affected by Ocular Hypertension in the Glaucomatous Male and Female Mouse Retina by Label-Free Proteomics Khadiza Zaman,1 Autumn B. Morgan,2 Katalin Prokai-Tatrai,1 Denis M. Inman,2 Laszlo Prokai1
PURPOSE. To identify of proteins and affected by increase of intraocular pressure in the magnetic microbead model of glaucoma in the retinae of mice considering sex as biological variable. METHODS. A sustained increase of intraocular pressure was achieved through injections of paramagnetic polystyr...
ORGANISM(S): Mus musculus (Mouse) 
2026-09-14 | PXD073136 | Pride
Label-free proteomics Glaucoma Sex as biological variable Pathway analysis Mouse Bioinformatics Retina Magnetic microbead model Protein interaction networks 
ProteomicsComparative Proteomics Analysis Reveals Unique Early Signaling Response of Saccharomyces cerevisiae to Oxidants with Different Mechanism of Action Prajita Pandey 1,‡, Khadiza Zaman 2, ‡, Laszlo Prokai 2 , and Vladimir Shulaev 1,*
The early signaling events involved in oxidant recognition and triggering of oxidant-specific defense mechanisms to counteract oxidative stress still remains largely elusive. Our discovery driven comparative proteomics analysis revealed unique early signaling response of yeast Saccharomyces cerevisi...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2021-01-04 | PXD022685 | Pride
Oxidative stress  reactive oxygen species  antioxidants  global untargeted proteomics  tor signaling  ran signaling  mapk cascade 
ProteomicsProteomics-Based Identification of Retinal Protein Networks Impacted by Elevated Intraocular Pressure in the Hypertonic Saline Injection Model of Experimental Glaucoma
Elevated intraocular pressure is considered a major cause of glaucomatous retinal neurodegeneration. To facilitate a better understanding of the underlying molecular processes and mechanisms, we report a study focusing on alterations of the retina proteome by induced ocular hypertension in a rat mod...
ORGANISM(S): Rattus norvegicus (Rat) 
2023-10-24 | PXD042729 | Pride
Retina proteomics  glaucoma  ocular hypertension  brown norway rat model  bioinformatics  pathway analysis  protein networks 
UnknownAnalysis of the effect of locally applied inhomogeneous static magnetic field-exposure on mouse ear edema--a double blind study.
Not available
S-EPMC4335006 | biostudies-literature
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