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TranscriptomicsChromatin immunoprecipitation genome wide binding sites of Oct4, Sox2, and Nanog in human
The transcription factors Oct4, Sox2, and Nanog have essential roles in early development and are required for the propagation of undifferentiated embryonic stem (ES) cells in culture. To gain insights into transcriptional regulation of human ES cells, we have identified Oct4, Sox2, and Nanog target...
ORGANISM(S): Homo sapiens 
2005-09-23 | E-WMIT-5 | biostudies-arrayexpress
TranscriptomicsChromatin immunopreciptiation of H2AZ in mouse embryonic stem cells and neural precursor cells
Elucidating how chromatin organization influences gene expression patterns and ultimately cell fate is fundamental to understanding development and disease. Histone variants have emerged as key regulators of genome function by creating specialized chromatin domains. The histone variant H2AZ plays an...
ORGANISM(S): Mus musculus 
2009-01-22 | E-TABM-556 | biostudies-arrayexpress
TranscriptomicsChromatin immunoprecipitation of mouse polycomb group (PcG) proteins in embryonic stem cells
Polycomb group (PcG) proteins are highly conserved from flies to mammals and many of these factors have essential roles in early embryonic development. PcG proteins comprise two multimeric complexes, the Polycomb Repressive complexes 1 and 2 (PRC1 and 2), which have been shown to repress transcript...
ORGANISM(S): Mus musculus 
2006-05-09 | E-WMIT-12 | biostudies-arrayexpress
TranscriptomicsRNA-sequencing of the human milk fat layer during colostrum, transitional, and mature stages of lactation
Human milk fat globules, by enveloping cell contents during their secretion into milk, are a rich source of mammary cell RNA. Here, we pair this non-invasive mRNA source with RNA sequencing technology to probe the milk fat layer transcriptome during three stages of lactation: colostral, transitional...
ORGANISM(S): Homo sapiens 
2013-07-22 | E-GEOD-45669 | biostudies-arrayexpress
UnknownGenome-wide joint meta-analysis of SNP and SNP-by-smoking interaction identifies novel loci for pulmonary function.
Not available
S-EPMC3527213 | biostudies-literature
UnknownMultiethnic meta-analysis identifies ancestry-specific and cross-ancestry loci for pulmonary function.
Not available
S-EPMC6065313 | biostudies-literature
UnknownGenetic determinants of telomere length from 109,122 ancestrally diverse whole-genome sequences in TOPMed.
Not available
S-EPMC9075703 | biostudies-literature
UnknownDynamic incorporation of multiple in silico functional annotations empowers rare variant association analysis of large whole-genome sequencing studies at scale.
Not available
S-EPMC7483769 | biostudies-literature
UnknownWhole Genome Sequencing Identifies CRISPLD2 as a Lung Function Gene in Children With Asthma.
Not available
S-EPMC6904857 | biostudies-literature
UnknownLoci associated with ischaemic stroke and its subtypes (SiGN): a genome-wide association study.
Not available
S-EPMC4912948 | biostudies-literature
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