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ProteomicsRepurposing human kinase inhibitors to create an antibiotic active against drug-resistant Staphylococcus aureus
To combat methicillin-resistant Staphylococcus aureus (MRSA) infections novel drugs are desperately needed. From a screen, we found that the anti-cancer drug sorafenib effectively kills MRSA strains. By synthetic variation of key structural features, we identified a potent analog, PK150, exhibiting ...
ORGANISM(S): Staphylococcus aureus 
2019-09-09 | PXD012946 | Pride
Full proteome Affinity-based protein profiling (afbpp) Q exactive plus Chemical proteomics Staphylococcus aureus subsp. aureus nctc 8325 Secretome Surfaceome Orbitrap fusion 
UnknownAge-dependent expression of stress and antimicrobial genes in the hemocytes and siphon tissue of the Antarctic bivalve, Laternula elliptica, exposed to injury and starvation.
Not available
S-EPMC3857432 | biostudies-literature
UnknownRadiation Response of Human Cardiac Endothelial Cells Reveals a Central Role of the cGAS-STING Pathway in the Development of Inflammation.
Not available
S-EPMC7709117 | biostudies-literature
UnknownBosutinib Versus Imatinib for Newly Diagnosed Chronic Myeloid Leukemia: Results From the Randomized BFORE Trial.
Not available
S-EPMC5966023 | biostudies-literature
ProteomicsRadiation response in human cardiac endothelial cells investigated by DIA-MS
The endothelium is the barrier separating blood and tissue. Radiation-induced enhanced inflammation leading to permeability of this barrier may increase the risk of cardiovascular disease. The aim of this study was to investigate the onset of endothelial inflammatory pathways after radiation exposur...
ORGANISM(S): Homo sapiens (Human) 
2020-11-02 | PXD020735 | Pride
Ionizing radiation Proteomics Ddb2 Inflammation Endothelial cells Cgas-sting-pathway Data-independent acquisition Stat1 
UnknownSAPS 3--From evaluation of the patient to evaluation of the intensive care unit. Part 1: Objectives, methods and cohort description.
Not available
S-EPMC1315314 | biostudies-literature
ProteomicsIsotope and proteomics evidence for ancient mobility and sex bias of Pre-Pottery Neolithic Jericho in Southern Levant
The transition from mobility to more sedentism is one of the essential processes at the pre-pottery stage of human societies, which takes place asynchronously in different communities in different regions. Being one of the representatives and long-termly occupied sites in the southern Levant, Jerich...
ORGANISM(S): Homo Sapiens 
2022-10-08 | PXD037215 |
ProteomicsProtective immune trajectories in early viral containment of non-pneumonic SARS-CoV-2 infection
The antiviral immune response to SARS-CoV-2 infection can limit viral spread and prevent development of pneumonic COVID-19. However, the protective immunological response associated with successful viral containment in the upper airways remain unclear. Here, we combine a multiomics approach with lon...
ORGANISM(S): Homo sapiens (Human) 
2022-01-17 | PXD030785 | Pride
Human Plasma Sars-cov-2 Proteomics Covid-19 
TranscriptomicsENCODE Transcript Mapping for Total RNA from Human NB4 Cells untreated, treated with RA, and treated with TPA
Transcript Mapping on Affymetrix ENCODE arrays for Total RNA from 4 different samples (2 or 3 technical replicates of each). All of the four same NB4 samples have also been treated with Retanoic Acid (RA) (2 or 3 technical replicates of each). Three of the four same NB4 samples have also been treate...
ORGANISM(S): Homo sapiens 
2010-06-10 | E-GEOD-2679 | biostudies-arrayexpress
GenomicsHypertension delays viral clearance and exacerbates airway hyperinflammation in patients with COVID-19
In coronavirus disease 2019 (COVID-19), hypertension and cardiovascular diseases are major risk factors for critical disease progression. However, the underlying causes and the effects of the main anti-hypertensive therapies-angiotensin-converting enzyme inhibitors (ACEIs) and angiotensin receptor b...
EGAS00001004772 | EGA
2019 novel coronavirus infection 2019-nCoV infection coronavirus disease 2019 COVID-19 SARS-coronavirus 2 SARS-CoV-2 severe acute respiratory syndrome coronavirus 2 
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