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ProteomicsHomologous recombination repair and cholesterol-mediated drug efflux induce dose-dependent chemoresistance in nutrient-deprived neuroblastoma cells
Neuroblastoma is a solid pediatric tumor with heterogeneous clinical behaviors. Chemotherapy is widely used to treat neuroblastoma. However, dose-dependent responses and chemoresistance mechanisms of neuroblastoma cells to anticancer drugs remain challenges in various conditions. Here, we investigat...
ORGANISM(S): Homo sapiens (Human) 
2021-03-25 | PXD014648 | Pride
Human Neuroblastoma Phosphoproteomics Proteomics Topotecan Lc-ms/ms 
ProteomicsHypoxia increases the methylated histones to prevent histone clipping and redistribution of heterochromatin during Raf-induced senescence.
Hypoxia in stem cell niches and inner core of solid tumors contributes to cellular senescence and differentiation inhibition. It directly increases histone methylationby inhibiting the activities of O2-and α-ketoglutarate (α-KG)-dependent histone lysine demethylases. This study is the first to demon...
ORGANISM(S): Homo sapiens (Human) 
2024-11-27 | PXD033971 | Pride
Human Top-down Histone Proteomics 
ProteomicsWideband PRM: Highly Accurate and Sensitive Method for High-Throughput Targeted Proteomics
Targeted mass spectrometry (MS) approaches, which are powerful methods for uniquely and confidently quantifying a specific panel of proteins in complex biological samples, play a crucial role in validation and clinical translation of protein biomarkers discovered by global proteomic profiling. Commo...
ORGANISM(S): Homo sapiens (Human) 
2024-08-14 | PXD048271 | Pride
Prm Targeted proteomics Parallel reaction monitoring Absolute quantification 
ProteomicsProteomic analysis of Adnp mutant mice
We report age-differential synaptic plasticity deficits associated with cognitive inflexibility and CaMKIIa hyperactivity in Adnp-mutant mice. These mice show impaired and inflexible contextual learning and memory additional to social and anxiety-related deficits in adults long after a marked decrea...
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
MSV000090257 | MassIVE
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