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ProteomicsIdentification of the intermolecular disulfide bonds between NPGPx and ZAP70
The tyrosine kinase, ζ-chain-associated protein of 70 kDa (ZAP70), is essential for T cell development and activation. However, it remains elusive whether a direct redox regulation affects ZAP70 activity upon TCR stimulation. Here, we showed that deficiency of non-selenocysteine containing phospholi...
ORGANISM(S): Homo sapiens (Human) 
2021-01-25 | PXD017034 | Pride
Zap70 Npgpx Disulfide bond 
ProteomicsIdentification of NPGPx-interacting proteins in activated T cells
The tyrosine kinase, ζ-chain-associated protein of 70 kDa (ZAP70), is essential for T cell development and activation. However, it remains elusive whether a direct redox regulation affects ZAP70 activity upon TCR stimulation. Here, we showed that deficiency of non-selenocysteine containing phospholi...
ORGANISM(S): Homo sapiens (Human) 
2021-01-25 | PXD017046 | Pride
T cell activation Zap70 Npgpx 
ProteomicsLoss of ST8SIA6 Promotes Colorectal Cancer Metastasis by Enhancing MUC16-Integrin β4 Signaling
This project investigates the functional role of the α2,8-sialyltransferase ST8SIA6 in the progression and metastasis of colorectal cancer. Through the use of Siglec-7-based enrichment and subsequent mass spectrometry analysis, MUC16 was identified as a primary glycoprotein affected by the loss of S...
ORGANISM(S): Homo sapiens (Human) 
2026-09-14 | PXD077963 | Pride
Colorectal cancer  metastasis  st8sia6  muc16  integrin β4  glycosylation  src/fak signaling 
UnknownThe Taiwan Precision Medicine Initiative provides a cohort for large-scale studies.
Not available
S-EPMC12675286 | biostudies-literature
UnknownHigher dose corticosteroids in hospitalised COVID-19 patients requiring ventilatory support (RECOVERY): a randomised, controlled, open-label, platform trial.
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S-EPMC11872607 | biostudies-literature
UnknownEmpagliflozin in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial.
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S-EPMC10957483 | biostudies-literature
UnknownSARS-CoV-2 vaccination modelling for safe surgery to save lives: data from an international prospective cohort study.
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S-EPMC7995808 | biostudies-literature
UnknownTiming of surgery following SARS-CoV-2 infection: an international prospective cohort study.
Not available
S-EPMC8206995 | biostudies-literature
UnknownSARS-CoV-2 infection and venous thromboembolism after surgery: an international prospective cohort study.
Not available
S-EPMC8652887 | biostudies-literature
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