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ProteomicsIntegrated Redox Proteomic Analysis Highlights New Mechanisms of Sensitivity to Silver Nanoparticles
Silver nanoparticles (AgNPs) are widely used nanomaterials in both commercial and clinical biomedical applications, but the molecular mechanisms underlying their activity remain elusive. In this work we profiled proteomics and redox proteomics changes induced by AgNPs in two lung cancer cell lines:...
ORGANISM(S): Homo sapiens (Human) 
2021-04-01 | PXD021493 | Pride
Silver nanoparticles Mitochondria Lung Reversible protein oxidation Proteomics 
ProteomicsHuman cerebrospinal fluid exosome, LC-MSMS
Quantitative proteomics analysis of exosomes isolated from cerebrospinal fluid of neuromyelitis optica patients detected potential distinctive disease markers capable of differentiating from multiple sclerosis and idiopathic longitudinally extensive transverse myelitis. Exosomes were enriched with ...
ORGANISM(S): Homo sapiens (Human) 
2016-09-27 | PXD002424 | Pride
Exosome Neuromyelitis optica Multiple sclerosis Cerebrospinal fluid 
ProteomicsQuantitative Proteomics Analysis of Mouse Plasma using Tandem-Mass Tagging (TMT)
The risk of breast cancer increases decades after ionizing radiation exposure, thereby linking aging intrinsically to the evolution of cancer. We hypothesized that radiation accelerates aging and carcinogenesis through similar pathways, specifically low-grade systemic inflammation. Here, we used the...
ORGANISM(S): Mus musculus (Mouse) 
2025-07-15 | PXD064950 | Pride
Mouse Tmt Plasma Bottom-up proteomics Lc-ms/ms 
ProteomicsProteomics data of plasma and bronchial alveolar lavage fluid collected from Acute respiratory distress syndrome patients
Acute respiratory distress syndrome (ARDS) is a severe and complex critical illness, characterized by its heterogeneous clinical presentation, making accurate clinical definition and effective treatment challenging. We hypothesized that advanced molecular analyses of matched plasma and bronchial alv...
ORGANISM(S): Homo sapiens (Human) 
2026-02-16 | PXD060437 | Pride
Ards Bronchial alveolar lavage fluid Plasma Redox proteomics Global proteomics 
ProteomicsSex Differences in Single Neuron Function and Proteomics Profiles Examined by Patch-Clamp and Mass Spectrometry in the Locus Coeruleus of the Adult Mouse
Aims: This study aimed to identify and characterize the intrinsic properties of locus coeruleus (LC) noradrenergic neurons in male and female mice using a genetic approach. We also sought to investigate sex-specific differences in membrane properties, action potential generation, and protein express...
ORGANISM(S): Mus musculus (Mouse) 
2024-05-24 | PXD045844 | Pride
Neuronal excitability Single-cell proteomics Noradrenergic neurons Locus coeruleus Sex-differences 
ProteomicsIDH3 serves as a redox switch that regulates energy metabolism and contractility in the heart under oxidative stress
Redox signaling and cardiac function are tightly linked. Still, it is largely unknown which specific protein targets are affected by reactive oxygen species (ROS) that underly the impaired inotropic effect in oxidative stress. Here, we combined a new chemogenetic mouse model (HMC HyPer-DAO transgeni...
ORGANISM(S): Mus musculus (Mouse) 
2025-07-15 | PXD033119 | Pride
Ros Total reversible oxidation Hyper-dao mice 
ProteomicsIDH3 serves as a redox switch that regulates mitochondrial energy metabolism and contractility in the heart under oxidative stress
Redox signaling and cardiac function are tightly linked. Still, it is largely unknown which specific protein targets are affected by reactive oxygen species (ROS) that underly the impaired inotropic effect in oxidative stress. Here, we combined a new chemogenetic mouse model (HMC HyPer-DAO transgeni...
ORGANISM(S): Mus musculus (Mouse) 
2023-04-21 | PXD037987 | Pride
Heart Mouse Hyperdao Redox proteomics 
ProteomicsRedox proteomics analysis of head and neck cancer cell model of radiation resistance
Quantitative redox proteomics analysis was performed using the SCC-61/rSCC-61 matched model system of radiation resistance in human head and neck squamous cell carcinoma.
ORGANISM(S): Homo sapiens (Human) 
2023-03-10 | PXD029053 | Pride
Human Head and neck cancer cell lines Redox proteomics Cosmro 
ProteomicsIdentification of phosphorylation sites on Abl2
The catalytic activity of Abl family kinases is tightly regulated in cells by a complex set of intra- and intermolecular interactions and post-translational modifications. Abl family kinases are activated by diverse cellular stimuli, one of them being receptor tyrosine kinase signaling. For example,...
ORGANISM(S): Homo sapiens (Human) 
2022-02-17 | PXD025896 | Pride
Human Abl2 Pdgfr-beta 
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