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ProteomicsA folded conformation of MukBEF and Cohesin
PleasStructural maintenance of chromosomes (SMC)-kleisin complexes organize chromosomal DNAs in all domains of life, where they have key roles in chromosome segregation, DNA repair and regulation of gene expression. They function through topological entrapment and active translocation of DNA, but th...
ORGANISM(S): Escherichia coli 
2019-03-01 | PXD012370 | Pride
Condensin Structural maintenance of chromosomes Loop extrusion Smc proteins Crosslinking Mukbef Cohesin Dna translocation Kleisin 
ProteomicsA folded conformation of MukBEF and Cohesin
Structural maintenance of chromosomes (SMC)-kleisin complexes organize chromosomal DNAs in all domains of life, where they have key roles in chromosome segregation, DNA repair and regulation of gene expression. They function through topological entrapment and active translocation of DNA, but the und...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2019-03-01 | PXD012377 | Pride
Condensin Structural maintenance of chromosomes Loop extrusion Smc proteins Crosslinking Mukbef Cohesin Dna translocation Kleisin 
ProteomicsInterrogating the interaction of fission yeast RNA-binding protein Puf3 with the Ccr4-Not complex using crosslinking mass spectrometry
mRNA decay is a key determinant of gene regulation, initiated by the shortening of mRNA poly(A) tails by the CCR4-NOT deadenylation complex. Specificity is achieved through RNA adaptors—RNA-binding proteins that recruit CCR4-NOT to specific substrate mRNAs in a regulated manner. However, the molecul...
ORGANISM(S): Schizosaccharomyces pombe 927 
2025-09-03 | PXD055147 | Pride
Crosslinking ms Idr Protein-protein interaction Rna binding protein puf3 Ccr4-not complex 
ProteomicsCryo-EM structures of holo condensin reveal a subunit flip-flop mechanism
This data is from BS3 crosslinked condensin tetramer How protein complexes of the SMC family fold DNA into the large loops that are fundamental for the 3D organization of genomes is a central unresolved question of chromosome biology. We used electron cryomicroscopy to investigate the reaction cycle...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2020-07-28 | PXD019275 | Pride
Condensin Tetramer Bs3 Crosslinking 
ProteomicsCryo-EM structures of holo condensin reveal a subunit flip-flop mechanism
This data is from sulfo-SDA crosslinked condensin pentamer. Two datsets, one without atp aand one with ATP. How protein complexes of the SMC family fold DNA into the large loops that are fundamental for the 3D organization of genomes is a central unresolved question of chromosome biology. We used el...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2020-07-28 | PXD019274 | Pride
Condensin Bs3 Crosslinking 
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