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TranscriptomicsHCT116 cells isogenic for p53 expression upon treatment with actinomycin D and nutlin-3
HCT116 wild type cells express p53. The isogenic HCT116 p53KO cells have the p53 gene knocked out. Cells were treated for 16 hours. Dosages for actinomycin D treatment was 1 nM, 10 nM, and 100 nM. Dosage for nutlin-3 was 4 uM. Keywords: dose response Measuring the gene expression profile of the is...
ORGANISM(S): Homo sapiens 
2010-06-24 | E-GEOD-12459 | biostudies-arrayexpress
ProteomicsAlterations of Ceramide Synthesis Induce PD-L1 Internalization and Signaling to Regulate Tumor Metastasis and Immunotherapy Response
Programmed death-ligand 1, PD-L1 (CD274) facilitates immune evasion and exerts pro-survival functions in cancer cells. Here, we report a new mechanism whereby internalization of PD-L1 in response to alterations of bioactive lipid/ceramide metabolism by ceramide synthase 4 (CerS4) induces sonic-hedge...
ORGANISM(S): Mus musculus (Mouse) 
2025-05-07 | PXD053108 | Pride
Sonic-hedgehog Ceramide Sphingolipid Cers4 Pd-l1 Metastasis Immunotherapy 
UnknownBrain Endothelial P-Glycoprotein Level Is Reduced in Parkinson's Disease via a Vitamin D Receptor-Dependent Pathway.
Not available
S-EPMC7696047 | biostudies-literature
UnknownPlasma GDF15 levels associated with circulating immune cells predict the efficacy of PD-1/PD-L1 inhibitor treatment and prognosis in patients with advanced non-small cell lung cancer.
Not available
S-EPMC9889409 | biostudies-literature
GenomicsGut microbiome modulates response to anti PD1 immunotherapy in metastatic melanoma patients
There is a growing appreciation of the role of the microbiome in cancer, and evidence in pre-clinical models that the gut microbiome may modulate responses to immune checkpoint blockade though this has not been well-characterized in patients. We analyzed the oral (n=86)and gut (n=43) 16S microbiome ...
EGAS00001002698 | EGA
UnknownGenetic Link Determining the Maternal-Fetal Circulation of Vitamin D.
Not available
S-EPMC8490770 | biostudies-literature
ProteomicsSpatial Multi-Omics Reveals Region-Specific Molecular Signatures in a 6-OHDA Model of Parkinson’s Disease
Parkinson’s disease (PD) is characterized by complex molecular and circuit-level alterations that extend beyond dopaminergic neurodegeneration, yet the spatial integration of metabolic and proteomic changes remains insufficiently explored. Here, we combined time-of-flight secondary ion mass spectrom...
ORGANISM(S): Mus musculus (Mouse) 
2026-09-28 | PXD071834 | Pride
UnknownThe Chinese herb polyphyllin D sensitizes ovarian cancer cells to cisplatin-induced growth arrest.
Not available
S-EPMC11824142 | biostudies-literature
UnknownCinacalcet lowering of serum fibroblast growth factor-23 concentration may be independent from serum Ca, P, PTH and dose of active vitamin D in peritoneal dialysis patients: a randomized controlled study.
Not available
S-EPMC3669111 | biostudies-literature
UnknownNrf2 Activated by PD-MSCs Attenuates Oxidative Stress in a Hydrogen Peroxide-Injured Retinal Pigment Epithelial Cell Line.
Not available
S-EPMC12649114 | biostudies-literature
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