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MetabolomicsMechanistic insights into the biological activity of S-Sulfocysteine in CHO cells using a multi-omics approach
S-Sulfocysteine (SSC), a bioavailable L-cysteine derivative (Cys), is known to be taken up and metabolized in Chinese hamster ovary (CHO) cells used to produce novel therapeutic biological entities. To gain a deeper mechanistic insight into the SSC biological activity and metabolization, a multi-omi...
2024-08-08 | MTBLS7424 | MetaboLights
GenomicsMalania oleifera cultivar:Malania oleifera Chun et S. Lee
Malania oleifera cultivar:Malania oleifera Chun et S. Lee Genome sequencing
PRJNA429319 | ENA
TranscriptomicsTranscription profiling of S. pombe reveals Cyclin dependent kinase inhibits re-initiation of a normal S-phase program during G2
To achieve faithful replication of the genome once in each cell cycle, re-initiation of S-phase is prevented in G2 and origins are restricted from re-firing within S-phase. We have investigated the block to re-replication during G2 in fission yeast. The DNA synthesis that occurs when G2/M cyclin d...
ORGANISM(S): Schizosaccharomyces pombe 
2009-05-13 | E-MTAB-105 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human U266, MM.1s, KMS11, 8226/S multiple myeloma cell lines treated with arsenic
We used microarrays to examine changes in gene expression in multiple myeloma cell lines following treatment with arsenic trioxide and darinaparsin Experiment Overall Design: Four multiple myeloma cell lines (U266, MM.1s, KMS11, 8226/S) were treated with either arsenic trioxide (ATO) for 6, 24, or 4...
ORGANISM(S): Homo sapiens 
2009-02-01 | E-GEOD-14519 | biostudies-arrayexpress
TranscriptomicsTranscriptome profiling of human anaplastic meningioma IOMM-Lee cells following silencing of HuR (Human antigen R) gene expression by siRNA
The human anaplastic meningioma IOMM-Lee cells were cultured in Dulbecco’s modified Eagle’s medium (Life Technologies, Carlsbad, California, USA) supplemented with 10% fetal bovine serum, 100 U/ml penicillin, and 100 mg/ml streptomycin, at 37°C in 20% O2 (5% CO2). HuR silencing was achieved by ...
ORGANISM(S): Homo sapiens 
2017-07-01 | E-MTAB-4999 | biostudies-arrayexpress
TranscriptomicsGene expression profiles of NIH3T3 cells stably transfected with the plasmids encoding the wild type PreS/S gene or the nonsense mutant gene (sW182*) of HBV.
Background and Aims: Whether hepatitis B virus (HBV) could play a direct role in hepatocarcinogenesis remains uncertain. The 3' end nonsense mutations of HBV PreS/S gene have been found to encode transcriptional transactivation activity, suggesting these mutations may contribute to HBV-associated on...
ORGANISM(S): Mus musculus 
2014-07-30 | E-GEOD-50180 | biostudies-arrayexpress
TranscriptomicsIn Vivo Mapping of Arabidopsis Scaffold/Matrix Attachment Regions Reveals Link to Nucleosome-Disfavoring Poly(dA:dT) Tracts
Scaffold or matrix attachment regions (S/MARs) are found in all eukaryotes. The pattern of distribution and genomic context of S/MARs is thought to be important for processes such as chromatin organization and modulation of gene expression. Despite the importance of such processes, much is unknown a...
ORGANISM(S): Arabidopsis thaliana 
2014-02-03 | E-GEOD-45549 | biostudies-arrayexpress
ProteomicsTGFBR2-dependent Alterations of Exosomal Cargo in DNA Mismatch Repair-deficient HCT116 Colorectal Cancer Cells
DNA mismatch repair-deficient colorectal tumors (CRC) frequently show coding microsatellite frameshift mutations in the MSI tumor driver Transforming Growth Factor Beta Receptor Type 2 (TGFBR2) leading to cellular alteration of MSI tumor cells [Lee, J., Warnken, U., Schnölzer, M., Gebert, J. & Kopit...
ORGANISM(S): Homo sapiens (Human) 
2017-04-07 | PXD005620 | Pride
Dna mismatch repair deficiency Lc-msms Transforming growth factor beta receptor type 2 Colorectal cancer Microsatellite instability Exosomes Proteomics 
ProteomicsEpigenetic resetting in the Parkinson's disease entail histone modification remodeling.
Parkinson's disease (PD) is a progressive neurodegenerative disorder characterized by the loss of dopaminergic neurons (DN) in the substantia nigra and disrupted cellular maintenance. Here, we demonstrate that NDST3-mediated epigenetic reprogramming halts neuronal degeneration and restores motor...
ORGANISM(S): Homo sapiens (Human) 
2026-03-16 | PXD067971 | Pride
Human Tmt Parkinson's Organoid Lc-ms/ms 
ProteomicsS-Trap eliminates Pluronic F68 and cell culture media polymers for effective proteomic analysis of mammalian cell bioreactor supernatants
Proteomic analysis of bioreactor supernatants can inform on cellular metabolic status, viability, and productivity, as well as product quality, which can in turn help optimize bioreactor operation. Incubating mammalian cells in bioreactors requires the addition of polymeric surfactants such as Pluro...
ORGANISM(S): Homo sapiens (Human) Saccharomyces cerevisiae (Baker's yeast) 
2020-06-30 | PXD017214 | Pride
Polymer contaminants Alkylation Bottom-up proteomics Mass spectrometry Sp3 Sample preparation S-trap Bioreactor samples 
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