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TranscriptomicsSub1 occupancy in yeast cells in exponential growth condition
A genome-wide location analysis by ChIP on chip of the gene occupancy by Sub1 was undertaken to define the gene targets of Sub1 in vivo. Chromatin immunoprecipitation (ChIP) assays were performed on epitope-tagged Sub1-3HA cross-linked chromatin from exponentially growing cells. Immunopurified DNA a...
ORGANISM(S): Saccharomyces cerevisiae 
2009-08-27 | E-GEOD-11054 | biostudies-arrayexpress
ProteomicsNanomaterials trigger functional responses in primary human immune cells
Targeting the immune system with nanoparticles (NPs) to deliver immunomodulatory molecules emerged as a solution to address intra-tumoral immunosuppression and enhance therapeutic response. While the potential of nanoimmunotherapies in reactivating immune cells has been evaluated in several preclini...
ORGANISM(S): Homo sapiens (Human) 
2025-10-27 | PXD056695 | Pride
Nanomaterials  human lymphocytes  nlc-ms/ms  sp3-spe  differential analysis 
TranscriptomicsAbnormal Wnt and PI3Kinase signaling in the malformed intestine of lama5 deficient mice
Laminins are major constituents of basement membranes and are essential for tissue homeostasis. Laminin-511 is highly expressed in the intestine and its absence causes severe malformation of the intestine and embryonic lethality. To understand the mechanistic role of laminin-511 in tissue homeostasi...
ORGANISM(S): Mus musculus 
2012-06-29 | E-GEOD-31334 | biostudies-arrayexpress
TranscriptomicsSynthetic double stranded RNA reliably induces innate immunity similar to a live viral vaccine in humans
Adjuvants are critical for the success of vaccines, and agonists for microbial pattern recognition receptors are promising new candidates. A mechanism for the immune enhancing role of adjuvants is to stimulate innate immunity. We studied the innate immune response in humans to synthetic double stran...
ORGANISM(S): Homo sapiens 
2011-10-11 | E-GEOD-32862 | biostudies-arrayexpress
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