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TranscriptomicsStaphVar-DNA microarray analysis of accessory genome of community-acquired methicillin resistant Staphylococcus aureus
Approximatively 75% of the genome of S. aureus (“core” genome) are highly conserved between strains, whereas the remaining 25% (“accessory” genome) are composed of variable regions that are mostly composed of mobile genetic elements (MGE), containing virulence and resistance genes. We have developed...
ORGANISM(S): Staphylococcus aureus 
2009-02-14 | E-GEOD-13702 | biostudies-arrayexpress
TranscriptomicsAnalysis of transcriptome in ectopic versus orthotopic thyroid tissue.
Congenital hypothyroidism from thyroid dysgenesis (CHTD) is a sporadic disease characterized by defects in the differentiation, migration or growth of thyroid tissue. Of these defects, incomplete migration resulting in ectopic thyroid tissue is the most common (up to 80%). We obtained flashfrozen sa...
ORGANISM(S): Homo sapiens 
2010-10-28 | E-GEOD-16804 | biostudies-arrayexpress
TranscriptomicsMethylome analysis of congenital ectopic thyroids
To assess whether specific genes have relevant somatic genetic or epigenetic alterations in ectopic tissue, we used a combined analysis of transcriptome (confirmed by qRT-PCR on 68 genes), methylome, structural genome variations (copy number variants, CNVs) and miRNA profile of ectopic compared with...
ORGANISM(S): Homo sapiens 
2010-10-27 | E-GEOD-17581 | biostudies-arrayexpress
TranscriptomicsSomatic CNV profile of congenital ectopic thyroids
To assess whether specific genes have relevant somatic genetic or epigenetic alterations in ectopic tissue, we used a combined analysis of transcriptome (confirmed by qRT-PCR on 68 genes), methylome, structural genome variations (copy number variants, CNVs) and miRNA profile of ectopic compared with...
ORGANISM(S): Homo sapiens 
2010-10-27 | E-GEOD-17463 | biostudies-arrayexpress
TranscriptomicsIdentification of Lgr5-independent spheroid-generating progenitors of the mouse fetal intestinal epithelium
Immortal spheroids were generated from fetal mouse intestine using the culture system developed to culture organoids from adult intestinal epithelium. Spheroids are made of a monostratified polarized epithelium displaying a poorly differentiated intestinal phenotype. The proportion of spheroids gene...
ORGANISM(S): Mus musculus 
2014-01-21 | E-GEOD-49803 | biostudies-arrayexpress
TranscriptomicsGrowth arrest of human thyroid cancer cells 8505C after inhibition of TTF-1 transcriptional activity
Background: thyroid transcription factor-1 (TTF-1) is known to play key roles in thyroid organogenesis, in thyroid cell proliferation and in the expression of genes involved in thyroid differentiated function. Objective: to understand why many human thyroid cancer cell lines keep producing TTF-1 d...
ORGANISM(S): Homo sapiens 
2016-06-01 | E-GEOD-58243 | biostudies-arrayexpress
TranscriptomicsGrowth arrest of human thyroid cancer cells 8505C after inhibition of TTF-1 transcriptional activity
Background: thyroid transcription factor-1 (TTF-1) is known to play key roles in thyroid organogenesis, in thyroid cell proliferation and in the expression of genes involved in thyroid differentiated function. Objective: to understand why many human thyroid cancer cell lines keep producing TTF-1 d...
ORGANISM(S): Homo sapiens 
2015-06-15 | E-GEOD-58587 | biostudies-arrayexpress
TranscriptomicsLgr4 is required for Paneth cell differentiation and maintenance of intestinal stem cells
Gene inactivation of the orphan G protein-coupled receptor Lgr4, a paralog of the epithelial stem cell marker Lgr5, results in 50% decrease of epithelial cell proliferation and 80% reduction in terminal differentiation of Paneth cells in postnatal mouse intestinal crypts. When cultured ex vivo, Lgr4...
ORGANISM(S): Mus musculus 
2012-03-10 | E-GEOD-27904 | biostudies-arrayexpress
TranscriptomicsGenome-wide analysis of TIAR RNA ligands in mouse macrophages before and after LPS stimulation
TIA-1 related protein (TIAR) is a RNA-binding protein involved in several steps of gene expression such RNA splicing and translation. TIAR contains three RNA recognition motifs (RRMs) allowing its interaction with specific sequences localized in the untranslated regions (UTRs) of several mRNAs. In ...
ORGANISM(S): Mus musculus 
2016-02-05 | E-GEOD-77577 | biostudies-arrayexpress
UnknownTHE OLFACTORY RECEPTOR Olfr78 PROMOTES DIFFERENTIATION OF ENTEROCHROMAFFIN CELLS IN THE MOUSE COLON
Not available
S-SCDT-10_1038-S44319-023-00013-5 | biostudies-other
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