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TranscriptomicsStrand specific sequencing illustrates the complex transcriptional response of Legionella pneumophila during infection
Legionella pneumophila is a Gram-negative facultative intracellular human pathogen with a distinct biphasic lifestyle. One of its primary environmental hosts in the free-living amoeba Acanthamoeba castellanii and its infection by L. pneumophila mimics that seen in human macrophages. Here we present ...
ORGANISM(S): Legionella pneumophila 
2011-02-11 | E-GEOD-27232 | biostudies-arrayexpress
ProteomicsInteractome of the Legionella pneumophila effector PieE
The in vivo interactome of the Legionella pneumophila effector PieE reveals binding to multiple Rab GTPases
ORGANISM(S): Legionella pneumophila 
2017-02-08 | PXD000706 | Pride
Legionella pneumophila 
TranscriptomicsTranscription profiling by array of Legionella pneumophila ppGpp knockout and relA over expression mutants.
Effect of ppGpp on transcript level after RelA overexpression (90 min). The cells are constructed in our lab. They are knock-out mutants in the production of ppGpp(guanosine tetraphosphate) of Legionella, complemented with an over-expression vector containing the relA gene to express the RelA prot...
ORGANISM(S): Legionella pneumophila 
2010-04-14 | E-MTAB-211 | biostudies-arrayexpress
ProteomicsLegionella pneumophila proteome
Legionella pneumophila cells were harvested during exponential growth (RP) and stationary growth (TP). VBNC cells were also anylzed. Protein subfractions were studied.
ORGANISM(S): Legionella pneumophila subsp. pneumophila (strain Philadelphia 1 / ATCC 33152 / DSM 7513) 
2015-11-13 | PXD001926 | Pride
Whole cell proteome Extracellular proteome Legionella Surface proteome 
ProteomicsEffects of Copper on Legionella pneumophila Revealed via Viability Assays and Proteomics
This project examined changes in Legionella pneumophila strain 130b proteomics between copper exposed and control conditions.
ORGANISM(S): Legionella pneumophila 130b 
2024-08-08 | PXD051926 | Pride
Copper Legionella pneumophila Ahpd Amoebae Proteomics 
TranscriptomicsTranscription profiling of Dictyostelium discoideum wild type and dupA null after infection with Legionella pneumophila
The social amoeba Dictyostelium discoideum is vulnerable to infection by the pathogen that causes Legionnaire's Disease, Legionella pneumophila. Dictystelium cells lacking the dual-specificity phospahatase DupA are at least partially resistant to infection, and strikingly the expression profile of u...
ORGANISM(S): Dictyostelium discoideum 
2009-09-24 | E-TABM-509 | biostudies-arrayexpress
TranscriptomicsTranscriptome of Legionella pneumophila rpoS mutant in water
Legionella pneumophila is a water-borne pathogen, and thus survival in the aquatic environment is central to its transmission to humans. Hence, identifying genes required for its survival in water could help prevent Legionnaires’ disease outbreaks. In the present study, we investigate for the first ...
ORGANISM(S): Legionella pneumophila subsp. pneumophila str. Philadelphia 1 
2014-12-04 | E-GEOD-56258 | biostudies-arrayexpress
ProteomicsDevelopment of covalent probes to capture Legionella pneumophila effector enzymes
Upon infection of host cells Legionella pneumophila releases a multitude of effector enzymes into the hosts cytoplasm that hijack a plethora of cellular activities, including the hosts ubiquitination pathways. Effectors belonging to the SidE-family are involved in non-canonical serine phosphoribosyl...
ORGANISM(S): Homo sapiens (Human) Legionella pneumophila subsp. pneumophila Lp02 
2025-05-06 | PXD049797 | Pride
Legionella pneumophila Activity-based probe Ubiquitylation Adp-ribosylation Bacterial infection 
ProteomicsProteomics identification of CsrA-regulated proteins in Legionella pneumophila
The carbon storage regulator protein CsrA regulates cellular processes post-transcriptionally by binding to target-RNAs altering translation efficiency and/or their stability. In this dataset we identified proteins regulated by CsrA in the human bacterial pathogen Legionella pneumophila by labelfree...
ORGANISM(S): Legionella pneumophila str. Paris 
2017-02-13 | PXD004730 | Pride
Labelfree shotgun proteomics Legionella pneumophila Csra 
ProteomicsMolecular Characterization of LubX. AP-MS using Legionella lysate
Legionella pneumophila delivers over 300 effector proteins into the host cytosol. One of these effectors, LubX contains 2 U-box domains, and directs the proeosomal degradation of another translocated protein, SidH, however this 'metaeffector' activity is pooly understood. As part of our investigatio...
ORGANISM(S): Legionella pneumophila subsp. pneumophila (strain Philadelphia 1 / ATCC 33152 / DSM 7513) 
2020-01-27 | PXD001525 | Pride
Sidh Ap-ms Dits Ltq xl Lubx Legionella 
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