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ProteomicsA Network Approach to Identify Biomarkers of Differential Chemotherapy Response Using Patient-Derived Xenograft Models of Triple Negative Breast Cancer
The authors develop a novel computational algorithm that identified two signatures of differential response to platinum-based and taxane chemotherapies in breast cancer.
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2021-10-15 | MSV000088233 | MassIVE
ProteomicsBalanced Input from the tRNA Prenyltransferase MiaA Controls the Stress Resistance and Virulence Potential of Extraintestinal Pathogenic Escherichia coli
In Escherichia coli, the highly conserved enzymes MiaA and MiaB mediate the sequential prenylation and methylthiolation of adenosine-37 within tRNAs that decode UNN codons. We found that MiaA, but not MiaB, is critical to the fitness and virulence of extraintestinal pathogenic E. coli (ExPEC), a maj...
ORGANISM(S): Escherichia coli 
2022-02-14 | PXD024782 | Pride
Expec Trna modification Extraintestinal pathogenic escherichia coli Frameshifting Urinary tract infection Bacterial fitness Translation Translational regulation Sepsis Stress response Uropathogenic Miab Miaa Fidelity Proteome 
TranscriptomicsSmall molecule activation of PKM in cancer cells induces serine auxotrophy
Proliferating tumor cells use aerobic glycolysis to support their high metabolic demands. Paradoxically, increased glycolysis is often accompanied by expression of the lower activity PKM isoform, effectively constraining lower glycolysis. Here, we report the discovery of novel PKM activators with ...
ORGANISM(S): Homo sapiens 
2012-12-20 | E-GEOD-40191 | biostudies-arrayexpress
ProteomicsHuman dental calculus LC-MS/MS
The purpose of this study was to investigate oral microbiome and host proteins in archaeological human dental tissues using a shotgun proteomics approach. The research focuses on dental calculus (mineralized plaque), dentine, a carious lesion, and an alveolar bone abscess from the medieval site of D...
ORGANISM(S): Bos Taurus (ncbitaxon:9913) Homo Sapiens (ncbitaxon:9606) Ovis (ncbitaxon:9935) 
2016-10-23 | MSV000080279 | MassIVE
GenomicsNational Human Genome Research Institute Tumor Sequencing Project (TSP) - Lung Adenocarcinoma

The Tumor Sequencing Project (TSP) Consortium is a collaboration among participants at the Baylor College of Medicine Human Genome Sequencing Center, the Broad Institute Genome Sequencing Platform, the Dana Farber Cancer Institute, the Memorial Sloan-Kettering Cancer Center, the Genome Seque...

phs000144.v1.p1 | EGA
GenomicsPancreatic Cancer Sequencing Initiative
Pancreatic Cancer Sequencing Initiative for the International Cancer Genome Consortium at the Ontario Institute for Cancer Research.
EGAS00001000343 | EGA
GenomicsGenome Sequencing of Pancreatic Ductal Adenocarcinoma at The Human Genome Sequencing Center of Baylor College of Medicine (HGSC-BCM)

Pancreatic ductal adenocarcinomas (PDAC) is the 11th most common cancer in the USA but the 4th in fatalities. The onset and progression of cancer is driven by extensive rearrangement and mutation of the genome. We combined our capability to capture and enrich exome DNA with the next generation se...

phs000516.v1.p1 | EGA
UnknownImpact of cardiometabolic multimorbidity and ethnicity on cardiovascular/renal complications in patients with COVID-19.
Not available
S-EPMC8678560 | biostudies-literature
TranscriptomicsICGC Pancreas: Genomic analysis reveals roles for chromatin modification and axonguidance in pancreatic cancer
Pancreatic cancer (PC) is the fourth leading cause of cancer death with an overall 5-year survival rate of < 5%, a statistic that has changed little in almost 50 years. A deeper understanding of the underlying molecular pathophysiology is expected to advance the urgent need to develop novel therapeu...
ORGANISM(S): Homo sapiens 
2012-03-30 | E-GEOD-36924 | biostudies-arrayexpress
UnknownAzithromycin in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial.
Not available
S-EPMC7884931 | biostudies-literature
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