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MetabolomicsPlasma sphingolipid changes with autopsy-confirmed Lewy body or Alzheimer's pathology
Not available
ORGANISM(S): Homo sapiens 
ST000433 | MetabolomicsWorkbench
ProteomicsProteomic Profiling of the Substantia Nigra to Identify Determinants of Lewy Body Pathology and Dopaminergic Neuronal Loss
Proteinaceous aggregates containing alpha-synuclein protein called Lewy bodies in the substantia nigra is a hallmark of Parkinson's disease. The molecular mechanisms of Lewy body formation and associated neuronal loss remain largely unknown. To gain insights on proteins and pathways associated with ...
ORGANISM(S): Homo sapiens (Human) 
2022-08-11 | PXD019279 | Pride
Brain Lewy bodies Substantia nigra Lc-ms/ms 
ProteomicsIn Situ Proximity Labeling Identifies Lewy Pathology Molecular Interactions in the Human Brain
The intracellular misfolding and accumulation of alpha-synuclein into structures collectively called LP is a central phenomenon for the pathogenesis of synucleinopathies including Parkinson’s disease (PD) and Dementia with Lewy Bodies (DLB). Understanding the molecular architecture of LP is crucial ...
ORGANISM(S): Homo sapiens (Human) 
2022-02-22 | PXD028830 | Pride
In situ Biotinylation by antigen recognition Neuropathology Lewy pathology Alpha-synuclein 
TranscriptomicsA Study of Small RNAs from Cerebral Neocortex of Pathology-Verified Alzheimer’s Disease, Dementia with Lewy Bodies, Hippocampal Sclerosis, Frontotemporal Lobar Dementia, and Non-Demented Human Controls
MicroRNAs (miRNAs) are small (20-22 nucleotides) regulatory non-coding RNAs that strongly influence gene expression. Most prior studies addressing the role of miRNAs in neurodegenerative diseases (NDs) have focused on individual controls (n = 2), AD (n = 5), dementia with Lewy bodies (n = 4), hippoc...
ORGANISM(S): Homo sapiens 
2013-04-18 | E-GEOD-46131 | biostudies-arrayexpress
UnknownA reciprocal relationship between markers of genomic DNA damage and alpha-synuclein pathology in dementia with Lewy bodies.
Not available
S-EPMC11927131 | biostudies-literature
GenomicsInterrogating DNA methylation associated with Lewy body pathology in a cross brain-region and multi-cohort study
Interrogating DNA methylation associated with Lewy body pathology in a cross brain-region and multi-cohort study
PRJNA1502935 | ENA
GenomicsEpigenome-wide association study of human frontal cortex identifies differential methylation in Lewy body pathology
Epigenome-wide association study of human frontal cortex identifies differential methylation in Lewy body pathology
PRJNA839433 | ENA
UnknownSex differences for regional pathology in people with a high likelihood of Lewy body dementia phenotype based on underlying pathology.
Not available
S-EPMC11780110 | biostudies-literature
UnknownLewy pathology of the esophagus correlates with the progression of Lewy body disease: a Japanese cohort study of autopsy cases.
Not available
S-EPMC7785549 | biostudies-literature
UnknownSpatial transcriptomics reveals molecular dysfunction associated with cortical Lewy pathology.
Not available
S-EPMC10966039 | biostudies-literature
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