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MetabolomicsIntegrated analysis of therapeutic efficacy and resistance mechanisms of lytic phages targeting ST218 K57 CR-hvKp
Clinical infection caused by carbapenem-resistant hypervirulent Klebsiella pneumoniae (CR-hvKP) is gradually increasing and spreading across the world, and phage therapy is a viable application as an alternative to antibiotics. However, additional clinical application is still restricted by the phag...
2025-09-18 | MTBLS12480 | MetaboLights
GenomicsCombinatorial patterning of chromatin regulators uncovered by genome-wide location analysis in human cells
Hundreds of Chromatin Regulators (CRs) control chromatin structure and function by catalyzing and binding histone modifications, yet the rules governing these key processes remain obscure. Here, we present a systematic approach to infer CR function. We developed ChIP-string, a meso-scale assay that ...
ORGANISM(S): Homo sapiens 
2011-12-23 | E-GEOD-32509 | biostudies-arrayexpress
TranscriptomicsSIRT1 but not its increased expression is essential for lifespan extension in caloric restricted mice.
The SIRT1 deacetylase is one of the best-studied potential mediators of some of the anti-aging effects of calorie restriction (CR); but its role in CR-dependent lifespan extension has not been demonstrated. We previously found that mice lacking both copies of SIRT1 displayed a shorter median lifespa...
ORGANISM(S): Mus musculus 
2014-04-25 | E-GEOD-46895 | biostudies-arrayexpress
ProteomicsConfirmation of direct interaction between H3K56cr and GLYR1 by H3K*56cr Site-Link in living cells
As we have found that H3K56cr can crosslink with GLYR1 in living cells, we now perform H3K*cr Site-Link in GLYR1 overexpressed cells. The subsequent 365-nm light irradiation could activate the diazirine and covalently capture potential effector proteins on native chromatin in living cells. The cross...
ORGANISM(S): Homo sapiens (Human) 
2023-03-06 | PXD033960 | Pride
Plink Glyr1 H3k56cr 
UnknownIn Situ Spectral Kinetics of Cr(VI) Reduction by c-Type Cytochromes in A Suspension of Living Shewanella putrefaciens 200.
Not available
S-EPMC4939527 | biostudies-literature
UnknownUnlocking the in situ Li plating dynamics and evolution mediated by diverse metallic substrates in all-solid-state batteries.
Not available
S-EPMC9616501 | biostudies-literature
UnknownEffects of Incubation Conditions on Cr(VI) Reduction by c-type Cytochromes in Intact Shewanella oneidensis MR-1 Cells.
Not available
S-EPMC4872037 | biostudies-literature
MetabolomicsEnergy-stress-mediated AMPK activation inhibits ferroptosis

Energy stress depletes ATP and induces cell death. Here we identify an unexpected inhibitory role of energy stress on ferroptosis, a form of regulated cell death induced by iron-dependent lipid peroxidation. We found that ferroptotic cell death and lipid peroxidation can be inhibited by treatment...

2023-01-31 | MTBLS1399 | MetaboLights
TranscriptomicsTranscriptomics evaluation of hexavalent chromium toxicity in human dermal fibroblasts
Significant occupational and environmental exposures to hexavalent chromium, a metal with broad toxicity potential in humans, have been reported. In order to understand the mechanisms of dermal toxicity induced by hexavalent chromium, global gene expression profiling of human dermal fibroblasts expo...
ORGANISM(S): Homo sapiens 
2011-07-30 | E-GEOD-16349 | biostudies-arrayexpress
UnknownMechanochemical-Triggered Confined Coordination of Iron-Biomass Composites for Efficient Cr(VI) Reduction Under Circumneutral pH Via Accelerated Electron Extraction.
Not available
S-EPMC12005798 | biostudies-literature
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