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ProteomicsConfirmation of direct interaction between H3K56cr and GLYR1 by H3K*56cr Site-Link in living cells
As we have found that H3K56cr can crosslink with GLYR1 in living cells, we now perform H3K*cr Site-Link in GLYR1 overexpressed cells. The subsequent 365-nm light irradiation could activate the diazirine and covalently capture potential effector proteins on native chromatin in living cells. The cross...
ORGANISM(S): Homo sapiens (Human) 
2023-03-06 | PXD033960 | Pride
Plink Glyr1 H3k56cr 
ProteomicsLife-time study of premodified histone for Identification of chromatinized proteome defined by site-specific histone acylations in living cells
C13, N15 isotope labelled heavy lysine bearing the modification group, such as cr and bhb, were site-sepcifically incorporated into histone H3K56 in living cells for measurement of the modification life of H3K56cr and H3K56bhb without iinterference caused by endogenous histone modification. Utilizai...
ORGANISM(S): Homo sapiens (Human) 
2023-03-06 | PXD033958 | Pride
Heavy lysine H3k56 Life time Bhb Cr 
ProteomicsCrotonylomics sequencing of human non small cell lung cancer cell lines
Crotonylation is a crotonyl-coenzyme A (CoA)-mediated post-translational modification best known for its roles in epigenetic regulation. Histone lysine crotonylation (Kcr) has been reported to be involved in tumor-related biological functions such as DNA damage repair and immune infiltration. Here w...
ORGANISM(S): Homo sapiens (Human) 
2025-09-22 | PXD053030 | Pride
Human lung cancer egfr-tki resistance lc-ms 
GenomicsChIP-seq in parental and resistant non-small cell lung cancer (NSCLC) cells
Crotonylation is a crotonyl-coenzyme A (CoA)-mediated post-translational modification best known for its roles in epigenetic regulation. Histone lysine crotonylation (Kcr) has been reported to be involved in tumor-related biological functions such as DNA damage repair and immune infiltration. Here w...
ORGANISM(S): Homo sapiens 
2025-09-16 | GSE269560 | GEO
TranscriptomicsRNA-seq in parental and resistant non-small cell lung cancer (NSCLC) cells
Crotonylation is a crotonyl-coenzyme A (CoA)-mediated post-translational modification best known for its roles in epigenetic regulation. Histone lysine crotonylation (Kcr) has been reported to be involved in tumor-related biological functions such as DNA damage repair and immune infiltration. Here w...
ORGANISM(S): Homo sapiens 
2025-09-16 | GSE269805 | GEO
TranscriptomicsLinking chromatin acylation mark-defined proteome and genome in living cells
A generalizable strategy with programmable site-specificity for in situ profiling of histone modifications on unperturbed chromatin remains highly desirable but challenging. We herein developed a Single-site-resolved multi-omics (SiTomics) strategy for systematic mapping of dynamic modifications, an...
ORGANISM(S): Homo sapiens 
2023-01-27 | GSE204854 | GEO
GenomicsLinking chromatin acylation mark-defined proteome and genome in living cells
A generalizable strategy with programmable site-specificity for in situ profiling of histone modifications on unperturbed chromatin remains highly desirable but challenging. We herein developed a Single-site-resolved multi-omics (SiTomics) strategy for systematic mapping of dynamic modifications, an...
ORGANISM(S): Homo sapiens 
2023-01-27 | GSE188778 | GEO
TranscriptomicsLinking chromatin acylation mark-defined proteome and genome in living cells
A generalizable strategy with programmable site-specificity for in situ profiling of histone modifications on unperturbed chromatin remains highly desirable but challenging. We herein developed a Single-site-resolved multi-omics (SiTomics) strategy for systematic mapping of dynamic modifications, an...
ORGANISM(S): Homo sapiens 
2023-01-27 | GSE188777 | GEO
GenomicsLinking chromatin acylation mark-defined proteome and genome in living cells
A generalizable strategy with programmable site-specificity for in situ profiling of histone modifications on unperturbed chromatin remains highly desirable but challenging. We herein developed a Single-site-resolved multi-omics (SiTomics) strategy for systematic mapping of dynamic modifications, an...
ORGANISM(S): Homo sapiens 
2023-01-27 | GSE204853 | GEO
OtherLinking chromatin acylation mark-defined proteome and genome in living cells
A generalizable strategy with programmable site-specificity for in situ profiling of histone modifications on unperturbed chromatin remains highly desirable but challenging. We herein developed a Single-site-resolved multi-omics (SiTomics) strategy for systematic mapping of dynamic modifications, an...
ORGANISM(S): Homo sapiens 
2023-01-27 | GSE204852 | GEO
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