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BHB is the major part of ketone body in plasm that is usually at low concentration. Dramatical increase of BHB is due to prologation fasting or diabetes. In addation to enegetic carrier for metabolic reprogramming, BHB is also involved in epigenetic regulation. Here, we illustrats the BHB-induced pr...
ORGANISM(S): Homo sapiens (Human) 
2025-07-04 | PXD051685 | Pride
Effect of BHB on transcriptional changes of antigen-stimulated CART19 cells
Bone Marrow Derived Macrophages(BMDMs) transcriptome analysis of control, LPS and LPS plus BHB group
C13, N15 isotope labelled heavy lysine bearing the modification group, such as cr and bhb, were site-sepcifically incorporated into histone H3K56 in living cells for measurement of the modification life of H3K56cr and H3K56bhb without iinterference caused by endogenous histone modification. Utilizai...
ORGANISM(S): Homo sapiens (Human) 
2023-03-06 | PXD033958 | Pride
This study examines the impact of β-hydroxybutyrate (BHB) on T cell function using RNA-seq, ATAC-seq, and H3K27ac CUT&RUN profiling to characterize BHB-induced transcriptional and epigenetic remodeling.
ORGANISM(S): Homo sapiens 
2025-12-09 | GSE312333 | GEO
Purpose: The purpose of this study was to compare the BMDMs transcriptome in the control LPS and LPS plus BHB group in order to identify the critical pathway that contributed to the inhibiton of BHB on M1 polarization. Methods: 1× 106 BMDMs were pre-treated with PBS or BHB for 1 hours before LPS adm...
ORGANISM(S): Mus musculus 
2022-04-06 | GSE152241 | GEO
Embryonic response to high beta-hydroxybutyrate (BHB) levels in postpartum dairy cows [methylation]
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