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Rationale: Despite the deleterious effects associated with elevated carbon dioxide (CO2), or hypercapnia, it has been hypothesized that CO2 can protect the lung from injury. However, the effects of chronic hypercapnia on the neonatal lung are unknown. Objectives: To determine whether chronic hyperca...
ORGANISM(S): Mus musculus 
FAM135B interacts with IFI16, inhibiting its ubiquitination and proteasomal degradation by competitively blocking its binding to the E3 ligase TRIM21, thereby initiating the IFI16-dependent STING signaling, ultimately leading to increased cytotoxic T cell activity.
ORGANISM(S): Homo Sapiens 
2025-09-09 | PXD068216 |

The aim of this study was to investigate the hepatoprotection of Schisandra chinensis Caulis polysaccharides (SCP) in the nonalcoholic fatty liver disease (NAFLD) induced by high-fat diet (HFD) in rats. A total of 30 Wistar rats were randomly divided into control group (CON), model group...

2021-08-24 | MTBLS3194 | MetaboLights
Acetylcholinesterase (AChE) is a cholinergic enzyme that hydrolyzes esters of the neurotransmitter acetylcholine (Ach). Aberrant activity of AChE is closely associated with various neurodegenerative diseases and cancer. Current chemical probes for AChE detection mostly rely on fluorescence readout a...
ORGANISM(S): Mus Musculus 
2025-04-24 | PXD063264 |
To elucidate the impact and mechanism of homocysteine on intracerebral hemorrhage at a system-wide level, we used a global phosphoproteomic approach combined with proteomics. Hyperhomocysteinaemia (HHcy) mice was induced by high methionine diet,and Experimental intracerebral hemorrhage was induced ...
ORGANISM(S): Mus Musculus 
2023-01-31 | PXD039748 |
Dissection of the mechanism of action of FGFR inhibitor by multi-omic analysis
ORGANISM(S): Homo Sapiens 
2025-02-05 | PXD060496 |
This mass spectrometry dataset was generated from RNA pull-down assays to identify proteins interacting with lncRNA MANCR in colorectal cancer cells (HCT116) and macrophages (THP-1)
ORGANISM(S): Homo Sapiens 
2026-01-04 | PXD072638 |
The polarization state of microglia exerts an influence on neuroinflammation and neural tissue repair after injury. Modulating microglial polarization is emerging as a potential therapeutic strategy for various types of neural injuries and neurodegenerative diseases. However, the causal relationship...
ORGANISM(S): Mus Musculus 
2025-12-24 | PXD072378 |
We report herein a set of activity-based probes (ABPs; P3-P7) based on various lysine-reactive covalent warheads capable of global profiling of ligandable lysine within BRDs in live cells and animals. Chemoproteomic experiments with P7 by utilizing 2-ethynylbenzaldehyde (EBA) identified 18 endogenou...
ORGANISM(S): Homo Sapiens Mus Musculus 
2025-04-10 | PXD058513 |
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