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GenomicsMNase digestion-sensitive nucleosomes in Saccharomyces cerevisiae
The structural complexity of nucleosomes underlies their functional versatility. Here we report a new type of complexity – nucleosome fragility, manifested as high sensitivity to micrococcal nuclease, in contrast to the common presumption that nucleosomes are similar in resistance to MNase digestio...
ORGANISM(S): Saccharomyces cerevisiae 
2011-01-24 | E-GEOD-26412 | biostudies-arrayexpress
ProteomicsGlycopeptide Biomarkers for HCC Detection in Patients with NASH
A comprehensive screening of site-specific N-glycopeptides in serum haptoglobin (Hp), a reporter molecule for aberrant glycosylation in HCC, has been performed to characterize glycopeptide markers for NASH-related HCCs.
ORGANISM(S): Homo sapiens (Human) 
2020-05-22 | PXD018502 | Pride
Human Serum Glycopeptide Lc-ethcd-ms/ms 
ProteomicsIntact N-glycopeptides in Serum Haptoglobin between HCC and Cirrhosis
A workflow for differential analysis of the microheterogeneity of site-specific intact N-glycopeptides of serum haptoglobin between early hepatocellular carcinoma (HCC) and liver cirrhosis has been developed.
ORGANISM(S): Homo sapiens (Human) 
2018-10-25 | PXD011239 | Pride
Human Serum Haptoglobin Lc-ethcd-ms/ms Liver 
ProteomicsSelective microautophagy of proteasomes is initiated by ESCRT-0 and is promoted by proteasome ubiquitylation
The proteasome is central to proteolysis by the ubiquitin-proteasome system under normal growth conditions but is itself degraded through macroautophagy under nutrient stress. A recently described AMPactivated protein kinase (AMPK)-regulated endosomal sorting complex required for transport (ESCRT)-d...
ORGANISM(S): Saccharomyces Cerevisiae 
2022-02-06 | PXD031469 |
MetabolomicsIntegrated multi-omics analysis and experimental verification reveal the involvement of the PI3K/Akt signaling pathway in myometrial fibrosis of adenomyosis.

This analysis established comprehensive metabolomic profiles of adenomyosis patients and revealed widespread alterations in the metabolome within normal and fibrotic myometrium. Integrated analysis shown significant associations between metabolomic data and fibrosis . This study is the first to d...

2025-05-12 | MTBLS11965 | MetaboLights
ProteomicsDifferent expressed proteins of HIV-infected long-term non-progress (LTNPs) and regular progressors (RPs)
To identify potential host factors promoting HIV-1 control and non-progressive infection, we employed mass spectrometry-based proteomic profiling to analyze three LTNPs and two PRs，in order to identify proteins expressed at higher levels in LTNPs.
ORGANISM(S): Homo Sapiens 
2024-05-30 | PXD050294 |
ProteomicsDifferent expressed proteins of HIV-infected long-term non-progressors (LTNPs) and regular progressors (RPs)
The whole blood samples were obtained from 3 LTNPs and 2 RPs HIV-1 infected patients, and the CD4+ T cells were isolated using anti-CD4-specific antibody-coated microbeads (130-045-101, Miltenyi Biotec, Germany) according to the manufacturer's instructions. Then the proteins extracted from the CD4+ ...
ORGANISM(S): Homo Sapiens 
2023-10-12 | PXD046078 |
ProteomicsInhibition of nuclear PTEN tyrosine phosphorylation enhances glioma radiation sensitivity through attenuated DNA repair
Glioblastoma (GBM) is the most lethal brain tumour that occurs in adults and treatment for GBM has been largely unsuccessful. Ionizing radiation (IR) and chemotherapeutic agents are employed as standard of care treatment for GBM patients and both result in DNA damage. Previous data identified phosph...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-08-07 | MSV000081423 | MassIVE
Proteomics5-fluorouracil (5-Fu) resistant Bel/5Fu cell line and its parent Bel7402 cell line
The extensive drug resistance of hepatocellular carcinoma (HCC) has become the main cause of chemotherapy failure. The mechanisms leading to drug resistance in tumor cells are not well understood. Previous studies demonstrated that plasma membrane proteins play important roles in mediating drug disp...
ORGANISM(S): Homo Sapiens 
2019-10-19 | PXD015917 |
ProteomicsThe proteome and phosphorylproteome of human early erythropoiesis
In order to revealed the multiple protein functional modules and kinases networks of human early erythropoiesis. We isolated the CD34+ cells drived from Human umbilical cord blood samples and induced to undergo erythropoiesis in vitro. Then, the cultured erythroid cells were sorted with FACS and sam...
ORGANISM(S): Homo Sapiens 
2022-08-03 | PXD035785 |
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