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ProteomicsIntegrative proteomic and phosphoproteomic profiling of testis from Wip1-knockout mice: insights into mechanisms of reduced fertility
Spermatogenesis plays an important role in the mammalian testis, involving in the complex processes of mitosis, meiosis, and spermiogenesis. Spermatogenesis may also be disrupted in the absence of the immunological and ‘fence’ functions of the BTB, resulting in male subfertility or infertility. Mice...
ORGANISM(S): Mus musculus (Mouse) 
2018-11-02 | PXD009220 | Pride
Fertility Proteomic Phosphoproteomic Knockout mice Testis Wip1 
ProteomicsMouse epididymis LC-MSMS - Male Fertility Potential Molecular Mechanisms Revealed by iTRAQ-Based Quantitative Proteomic Analysis of the Epididymis from Wip1-/- Mice
The wild-type p53-induced phosphatase 1 (WIP1) frustrated mice exhibited defects in reproductive organs. This study aimed to understand how Wip1 deficiency affects the spermatogenesis or maturation. We employed the Wip1-/- mouse model and conducted a gel-free iTRAQ LC-MS/MS based quantitative proteo...
ORGANISM(S): Mus musculus (Mouse) 
2019-01-16 | PXD010125 | Pride
Lc-msms Mouse Sperm Itraq Epididymis 
TranscriptomicsPorcine spleen_Haemophilus Parasuis infected_7days
Haemophilus parasuis(HPS) is a prominent swine pathogen that causes GlM-CM-$sser's disease characterized by fibrinous polyserositis, meningitis and arthritis; however, the molecular mechanisms underlying disease pathogenesis remains poorly understood, particularly the host counteraction to HPS invas...
ORGANISM(S): Sus scrofa 
2009-03-26 | E-GEOD-11787 | biostudies-arrayexpress
UnknownDraft genome of the leopard gecko, Eublepharis macularius.
Not available
S-EPMC5080775 | biostudies-literature
TranscriptomicsExpression data from Bama minipig hearts - high-fat, high-sucrose diet
In order to study the heart disorder that the long term, high energy diet caused, Bama miniature pigs were fed a high-fat, high-sucrose diet for 23 months. These pigs developed symptoms of metabolic syndrome and showed cardiac steatosis and hypertrophy with a greatly increased heart weight (1.82-fol...
ORGANISM(S): Sus scrofa 
2015-10-31 | E-GEOD-67890 | biostudies-arrayexpress
UnknownEfficacy and safety of bloodletting puncture and cupping in postherpetic neuralgia: A systematic review and meta‑analysis.
Not available
S-EPMC10801353 | biostudies-literature
UnknownAconine attenuates osteoclast-mediated bone resorption and ferroptosis to improve osteoporosis via inhibiting NF-κB signaling.
Not available
S-EPMC10682992 | biostudies-literature
UnknownAsymmetric distribution of cytokinins determines root hydrotropism in Arabidopsis thaliana.
Not available
S-EPMC6951336 | biostudies-literature
ProteomicsEvolutionary collateral sensitivity to pleuromutilins in vancomycin-resistant Enterococcus faecium
The rise of antibiotic resistance and decline of antibiotic discovery urgently calls for novel mechanistic understanding of pharmacological and evolutionary interactions between antibiotics and multidrug resistant bacteria to revitalize existing antibiotics. The evolutionary cross-resistance to anti...
ORGANISM(S): Enterococcus faecalis (Streptococcus faecalis) 
2022-05-20 | PXD030906 | Pride
Collateral sensitivity，vancomycin-resistant enterococcus faecium，pleuromutilin 
UnknownLoss of the common immune coreceptor BAK1 leads to NLR-dependent cell death.
Not available
S-EPMC7604517 | biostudies-literature
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