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MetabolomicsMyeloid PFKFB3-mediated glycolysis promotes kidney fibrosis
Excessive renal fibrosis is a common pathology in progressive chronic kidney diseases. Inflammatory injury and aberrant repair processes contribute to the development of kidney fibrosis. Myeloid cells, particularly monocytes/macrophages, play a crucial role in kidney fibrosis by releasing their proi...
2024-03-12 | MTBLS8278 | MetaboLights
ProteomicsAn Undesirable Side Effect of EDC-catalyzed Carboxyl Labeling Approach
Carbodiimide catalyzed carboxyl and amine conjugation (amidation) has been widely used to protect carboxyl groups. N-(3-dimethylaminopropyl)-N’-ethylcarbodiimide (EDC) is the most commonly used carbodiimide reagent in protein chemis-try due to its high efficiency and high solubility in aqueous media...
ORGANISM(S): Homo sapiens (Human) 
2020-12-10 | PXD020042 | Pride
Tyrosine Carboxyl protection C-tails Edc 
ProteomicsBasic Strong Cation Exchange Chromatography, BaSCX, a Highly Efficient Approach for C-Terminomic Studies Using LysargiNase Digestion
Decoding protein C-termini is a challenging task in protein chemistry using conventional chemical/enzymatic approaches. With the rapid development in modern mass spectrometer, many advanced mass spectrometry (MS) based protein C-termini analysis approaches have been established. Although great progr...
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) Caenorhabditis elegans 
2020-02-28 | PXD016317 | Pride
C-terminomics / lysarginase / scx / bascx / mass spectrometry 
TranscriptomicsGenome-wide maps of AGO1-bound small RNA in Arabidopsis leaves
We report flg22 regulate the accumulation of AGO1-bound small RNA in arabidopsis. We find that a number of miRNAs are up- or down-regulated by flg22, a well-studied PAMP. Examination of AGO1-bound small RNAs with or without flg22 treatment.
ORGANISM(S): Arabidopsis thaliana 
2010-02-25 | E-GEOD-20448 | biostudies-arrayexpress
ProteomicsHuman,squamous cell lung cancer,LC-MS/MS
We compared the proteome of primary SqCLC tumor tissue between patients with ER (< 10 months) vs. LR (> 30 months) following surgery. iTRAQ-based quantitative 2D LC-MS/MS proteomics were performed on 20 SqCLC tumor samples (10 ER, 10 LR) using a matched pair design in which each ER tumor sample was ...
ORGANISM(S): Homo sapiens (Human) 
2021-09-08 | PXD009383 | Pride
Human Lc-ms/ms Squamous cell lung cancer 
UnknownDesign, Synthesis, and Biological Activities of Novel 1,3,5-Trimethylpyrazole-Containing Malonamide Derivatives.
Not available
S-EPMC6385117 | biostudies-literature
ProteomicsProteomic analysis of whole blood to investigate the therapeutic effects of nervonic acid on cerebral ischemia-reperfusion injury in rats
Proteomic analysis of whole blood to investigate the therapeutic effects of nervonic acid on cerebral ischemia-reperfusion injury in rats
ORGANISM(S): Rattus Norvegicus 
2025-01-01 | PXD059362 |
UnknownInterleukin-16 enhances anti-tumor immune responses by establishing a Th1 cell-macrophage crosstalk through reprogramming glutamine metabolism in mice.
Not available
S-EPMC11893787 | biostudies-literature
ProteomicsThe effects of Cas5 on the protein biosynthesis of Candida albicans
Cas5, a transcriptional regulator of Candida albicans, has profound effects on the biosynthesis of cell wall proteins through regulating Candida albicans cell wall remodeling
ORGANISM(S): Candida Albicans 
PXD052043 |
ProteomicsCrocins ameliorate experimental immune checkpoint inhibitor-related myocarditis by targeting the Hpx/Nrf2/HO-1 pathway
Immune checkpoint inhibitors (ICIs) for cancer therapy may induce immune-related adverse events including myocarditis, which occurs infrequently but carries a high mortality rate. Crocins are the active constituents derived from Crocus sativus L. (Saffron), and have demonstrated various bioactivitie...
ORGANISM(S): Mus Musculus 
2025-12-27 | PXD072469 |
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