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Studies have analyzed the regulation mechanism of primordial germ cell (PGC) formation at the transcriptional level, but few at the protein level, showing the mechanism analysis of PGC formation not systematic. We collected embryonic stem cells and PGC using a novel sampling strategy and performed l...
ORGANISM(S): Gallus gallus (Chicken) 
2025-09-08 | PXD035490 | Pride
As germ cell precursor, primordial germ cells (PGCs) are widely used in transgenic animal production, regenerative medicine and other fields. However, the regulation mechanism of chicken PGCs is not incomplete, which leads to the insufficient amount of chicken PGCs obtained in vitro, which seriously...
ORGANISM(S): Gallus gallus (Chicken) 
2025-09-08 | PXD052543 | Pride
The combination of peginterferon and ribavirin is the standard treatment for chronic hepatitis C. Our recent clinical study suggests that ribavirin augments the induction of interferon stimulated genes (ISGs) in patients treated for HCV infection [1]. In order to further characterize the mechanism...
ORGANISM(S): Homo sapiens 
Recent identification of IL28B gene polymorphisms associated with hepatitis C virus (HCV) clearance suggests a role for type III interferons (IFNs) in hepatitis C infection. The function of type III IFNs in intrinsic antiviral immunity is poorly understood. Here we show that HCV infection of primar...
ORGANISM(S): Homo sapiens 
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