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ProteomicsProteomic analysis of glutamine deprivation in HepG2 cells
We applied the quantitative proteomics approach to estimate the relative abundance of proteins in HepG2 cells treated by glutamine deprivation. Two independent cultured cell lysates, namely control and glutamine deprivation, were marked with iTRAQ labels and subjected to LC-ESI-MS/MS analysis. The t...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-03-29 | MSV000080721 | MassIVE
ProteomicsProteomic response of S. aureus to alpha-mangostin
S. aureus isolate was inoculated and cultured to exponential growth phase (OD600 at 0.5) in TSB and divided into two groups, the control group and the drug treated group. alpha-mangostin was added to the drug treated group until a final concentration of 1/2× MIC reached, and DMSO added in the contro...
ORGANISM(S): Staphylococcus Aureus 
2022-10-17 | PXD037518 |
Proteomicsproteomic response of S. aureus with entrectinib treatment
S. aureus isolate was inoculated and cultured to exponential growth phase (OD600 at 0.5) in TSB and divided into two groups, the control group and the drug treated group. Entrectinib was added to the drug treated group until a final concentration of 1/2× MIC reached, and DMSO added in the control gr...
ORGANISM(S): Staphylococcus Aureus 
2022-11-23 | PXD038342 |
ProteomicsIntegration of transcriptome and proteome reveals relevant myelin features in ischaemic stroke mice
Through transcriptome and proteome sequencing data, combined with biological information methods, this study mined key myelin-related genes in IS, explored their relationship with other cerebrovascular diseases and their regulatory mechanisms in IS, and predicted potential drugs related to key genes...
ORGANISM(S): Mus Musculus 
2024-04-28 | PXD051812 |
ProteomicsStudy on the spatial effect of peripheral ApoE3 on regulating cadmium binding proteome and mechanism of cognitive impairment in the elderly
The experiment utilized a total of 54 five-week-old Sprague-Dawley rats, each weighing approximately 100 grams. These rats were randomly divided into 9 groups, consisting of 27 female and 27 male rats. Based on the intervention dose of cadmium (Cd), the rats were further randomly assigned into 3 mai...
ORGANISM(S): Rattus Rattus 
2025-04-16 | PXD063013 |
ProteomicsSirtuin 5-mediated desuccinylation of ALDH2 alleviates mitochondrial oxidative stress following acetaminophen-induced acute liver injury
WT mice and SIRT5 knockout mice were injected with APAP by intraperitoneal injection, and liver tissue specimens were taken 24 hours later for protein succinylation modification histology analysis
ORGANISM(S): Mus Musculus 
2024-02-24 | PXD050121 |
ProteomicsPBP inactivation and OXA treatment resulted in altered protein compositions of Staphylococcal membrane vesicles
The engineered Staphylococcus aureus strain RN4220Δagr/EDⅢ was treated with 1/4 MIC of Oxacillin (OXA), or used to construct pbp3 and pbp4 gene mutant strain. Then, the membrane vesicles (MVs) of parent strain (ΔagrMVs), OXA-treated strain (Δagr/OXAMVs), and pbp3/pbp4 mutants (Δagr/OXAMVs) were harv...
ORGANISM(S): Staphylococcus Aureus Subsp. Aureus Rn4220 
2024-10-21 | PXD057038 |
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