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MetabolomicsAge-, sex- and proximal-distal-resolved multi-omics identifies regulators of intestinal aging in non-human primates.

The incidence of intestinal diseases increases with age, but the regulators of gut aging and the molecules linking gut aging and diseases remain largely unknown. By profiling the transcriptome, proteome, phosphoproteome and metabolome of 104 Macaca fascicularis large intestinal tissues, ...

2023-12-14 | MTBLS7612 | MetaboLights
ProteomicsMechanism of isorhynchophylline in lipopolysaccharide-induced acute lung injury based on proteomic technology
Abstract Isorhynchophylline, a tetracyclic indole alkaloid, has anti-inflammatory and antioxidant activities against cardiovascular diseases and central nervous system disorders. Acute lung injury (ALI) is a manifestation of inflammation concentrated in the lungs and has a high incidence rate and mo...
ORGANISM(S): Mus musculus (Mouse) 
2024-06-23 | PXD050432 | Pride
Isorhynchophylline；acute lung injury；proteomic technology  tunel  rt-pcr  nano-lc-ms/ms 
UnknownNew tale on LianHuaQingWen: IL6R/IL6/IL6ST complex is a potential target for COVID-19 treatment.
Not available
S-EPMC8610116 | biostudies-literature
ProteomicsNoninvasive urinary protein signatures combined clinical information associated with Microvascular Invasion Risk in patients with HCC
Microvascular invasion (MVI) is the main factor affecting the prognosis of patients with hepatocellular carcinoma (HCC). There is an urgent need for reliable preoperative prediction of MVI indicators in order to formulate a reasonable treatment plan for patients.
ORGANISM(S): Homo Sapiens 
2022-10-13 | PXD037409 |
ProteomicsAutophagy and biotransformation affect sorafenib resistance in hepatocellular carcinoma
As a first-line drug for treating advanced hepatocellular carcinoma, the resistance to sorafenib has always attracted attention. However, most attention has been focused on a series of mechanisms related to drug resistance caused after sorafenib treatment. In this study, we used proteomic techniques...
ORGANISM(S): Homo Sapiens 
2023-02-24 | PXD040371 |
ProteomicsUtilizing Liquid Biopsy-Derived Extracellular Vesicle Protein Biomarkers for Diagnosis and Prognostic Assessment in Lung Squamous Cell Carcinoma
In the context of pulmonary nodules detected in imaging, there is currently a lack of highly effective and non-invasive methods for both diagnosing and prognosticating lung squamous cell carcinoma (LUSC). Therefore, in this study, we explored the potential of plasma-derived extracellular vesicles (E...
ORGANISM(S): Homo Sapiens 
2023-12-18 | PXD047893 |
ProteomicsCRL4AMBRA1 mediated progesterone receptor degradation drives progestin resistance and represents a therapeutic vulnerability in endometrial cancer
AMBRA1 ubiquitinates PR to ptomote progestin resistance in endometrial cancer
ORGANISM(S): Homo Sapiens 
2026-01-04 | PXD072640 |
ProteomicsCRL4AMBRA1 mediated progesterone receptor degradation drives progestin resistance and represents a therapeutic vulnerability in endometrial cancer
AMBRA1 ubiquitinates PR to ptomote progestin resistance in endometrial cancer
ORGANISM(S): Homo Sapiens 
2026-01-08 | PXD072904 |
ProteomicsAge-, sex- and proximal–distal-resolved multi-omics identifies regulators of intestinal aging in non-human primates
To determine the molecular landscape of large intestinal aging, we collected 104 pieces of fresh large intestinal tissue from 26 Macaca fascicularis and performed age-, location-, and sex-resolved multi-omics analyses, including transcriptomics, proteomics, phosphoproteomics and metabolomics.
ORGANISM(S): Macaca Fascicularis Fascicularis 
2024-01-18 | PXD039361 |
ProteomicsProteomics data of colorectal cancer
Paired tumor and distant normal tissues from a cohort of 104 colon cancer patients were collected at West China Hospital and snap-frozen in liquid nitrogen. The informed consent forms were signed by the participants or their family members.
ORGANISM(S): Homo Sapiens 
2023-01-11 | PXD039360 |
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