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UnknownDiscovery of TRPV4-Targeting Small Molecules with Anti-Influenza Effects Through Machine Learning and Experimental Validation.
Not available
S-EPMC11818416 | biostudies-literature
MetabolomicsMetabolomic profiling of colon tissue in loperamide-induced constipation mice treated with Rothia mucilaginosa

Untargeted metabolomics was performed on colon tissue from 26 C57BL/6 mice to investigate metabolic mechanisms underlying Rothia mucilaginosa-mediated constipation alleviation. Mice were divided into normal control (NC, n=8), loperamide-induced constipation model control (MC, n=8), and R. mucilag...

2026-04-27 | MTBLS13907 | MetaboLights
ProteomicsProteomic Analysis of the Capability to Enrich Rat Nucleus Pulposus Cell Membrane Proteins on Different Glucomannan Esters
Nucleus pulposus cells show unique phenotypes and morphology on different glucomannan esters. Various protein receptors on the membrane surface are involved in cell adhesion, morphology maintenance and phenotype regulation. In this project, the cell membrane proteins of the nucleus pulposus cells we...
ORGANISM(S): Rattus Norvegicus 
PXD054091 |
ProteomicsHistone phosphorylation integrates the hepatic glucagon-PKA-CREB gluconeogenesis program in response to fasting
To look for factors that may have preferential binding to H3S28ph and mediate the stimulation to gene expression.
ORGANISM(S): Mus Musculus 
2022-05-25 | PXD034125 |
ProteomicsLockd promotes myoblast proliferation and skeletal muscle regeneration through binding with DHX36 to facilitate unwinding of 5’UTR rG4 and translation of Anp32e mRNA
Adult muscle stem cells, also known as satellite cells (SCs) play pivotal roles in injury induced muscle regeneration and our knowledge of long non-coding RNA (lncRNA) functions in SCs remains limited. Here we identify a lncRNA, Lockd which is induced in activated SCs upon acute muscle injury. We de...
ORGANISM(S): Mus Musculus 
2022-05-24 | PXD033658 |
ProteomicsMass spectrometry of HCT116 cells
HCT116 cells were transfected with flag-pcDNA3.1 plasmids or flag-MST3 plasmids. Whole-cell extracts were prepared with a lysis buffer, lysed on ice for 10 min, centrifuged at 12,000 rpm for 10 min at 4°C, and the supernatant was collected. The anti-Flag antibody and protein A/G beads were added and...
ORGANISM(S): Homo Sapiens 
2024-03-09 | PXD050513 |
ProteomicsThe N-Myc-Responsive LncRNA MILIP Promotes Non-Homologous DNA End Joining to Alleviate Genotoxic Stress in Human Neuroblastoma
lncRNAMILIP promotes the NHEJ pathway through facilitating Ku70-Ku80 heterodimerization and is involved in the resistance to DNA-damaging therapeutics in neuroblastoma cells.
ORGANISM(S): Homo Sapiens 
PXD033372 |
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