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TranscriptomicsTranscription profiling of human cord lining epithelial cells after phage integrase mediated integration
The two obstacles that impede a wider application of genetically modified cells expressing therapeutic transgenes for ex vivo gene therapy are the immune mediated rejection of the transplanted cells, combined with their potential to cause iatrogenic oncogenesis. In this study we describe a new cellu...
ORGANISM(S): Homo sapiens 
2008-10-25 | E-GEOD-12510 | biostudies-arrayexpress
TranscriptomicsSingle-cell transcriptome analyses reveal signals to activate dormant neural stem cells.
Through single cell transcriptome analysis, we uncovered molecular signatures of CD133+/GFAP- ependymal (E) cells, CD133+/GFAP+ neural stem (B) cells, Dlx2+ neuroblasts (A cells), and Sox10+ oligodendrocyte progenitors (O cells) in the adult mouse forebrain neurogenic zone. prominent hub genes of th...
ORGANISM(S): Mus musculus 
2015-05-21 | E-GEOD-61288 | biostudies-arrayexpress
TranscriptomicsAnalysis of copy number change in cord lining epithelial cells after phage integrase mediated genomic integration.
The two obstacles that impede a wider application of genetically modified cells expressing therapeutic transgenes for ex vivo gene therapy are the immune mediated rejection of the transplanted cells, combined with their potential to cause iatrogenic oncogenesis. In this study we describe a new cellu...
ORGANISM(S): Homo sapiens 
2008-09-01 | E-GEOD-12629 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human MOLT4 cell lines before and after inhibition of gamma secretase to investigate NOTCH signaling in T-cell acute lymphoblastic leukemia cell lines
In T-cell acute lymphoblastic leukemia (T-ALL) NOTCH 1 receptors are frequently mutated. This leads to aberrantly high Notch signaling, but how this translates into deregulated cell cycle control and the transformed cell type is poorly understood. In this report, we analyze downstream responses resu...
ORGANISM(S): Homo sapiens 
2008-06-14 | E-GEOD-6495 | biostudies-arrayexpress
TranscriptomicsSequential Notch activation regulates ventricular chamber development
Ventricular chambers are essential for the rhythmic contraction and relaxation that occurs in every hearbeat throughout life. Congenital abnormalities in ventricular chamber formation cause severe human heart defects. How the early trabecular meshwork of myocardial fibres forms and subsequently deve...
ORGANISM(S): Mus musculus 
2016-02-12 | E-GEOD-67889 | biostudies-arrayexpress
TranscriptomicsExpression data from mouse kidney tissue
The role of the renin-angiotensin system in chronic kidney disease involves multiple peptides and receptors. Exerting antipodal pathophysiological mechanisms, renin inhibition and AT1 antagonism ameliorate renal damage. This is a comparison between the renin inhibitor aliskiren with the At1 antagoni...
ORGANISM(S): Mus musculus 
2012-11-05 | E-GEOD-34552 | biostudies-arrayexpress
ProteomicsApplication of integrated omics in aseptic loosening of prostheses after hip replacement
Aseptic loosening (AL) of artificial hip joints is the most common complication following hip replacement surgery. In the present study, second-generation high-throughput sequencing and mass spectrometry techniques were used to detect differentially expressed genes, proteins and metabolites in sampl...
ORGANISM(S): Homo Sapiens 
2024-12-14 | PXD058886 |
UnknownHypercompact TnpB and truncated TnpB systems enable efficient genome editing in vitro and in vivo.
Not available
S-EPMC10951260 | biostudies-literature
TranscriptomicsTranscription profiling of prostate tumor cell line AT1 inocculated into rats and then subjected to carbon ion or photon radiation
In the present study approximately 1 to 2 mm3 prostate tumor AT1 was inoculated subcutaneously in the right hind leg of adult male Copenhagen rats. When the tumor diameter exceeded 15 mm, tumors of 5 and 4 rats were irradiated with carbon ion radiation of 37 or 16Gy respectively. Tumors of 5 other r...
ORGANISM(S): Rattus norvegicus 
2008-07-18 | E-TABM-481 | biostudies-arrayexpress
ProteomicsDeubiquitinases that digest Met1 chains in Rice
Met1 type ubiquitination and deubiquitination are involved in the regulation of many fundamental processes such as inflammation and innate immunity, and their interference by pathogens can suppress immune responses in human cells. However, few plant-derived deubiquitinases (DUBs) against Met1 ubiqui...
ORGANISM(S): Oryza sativa (Rice) 
2022-10-15 | PXD032822 | Pride
Deubiquitinase Met1 chains Rice 
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