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MetabolomicsThe trans-omics landscape of COVID-19
The outbreak of coronavirus disease 2019 (COVID-19) is a global health emergency. Various omics results have been reported for COVID-19, but the molecular hallmarks of COVID-19, especially in those patients without comorbidities, have not been fully investigated. Here we collect blood samples from 2...
2021-10-06 | MTBLS2542 | MetaboLights
TranscriptomicsHypothalamic gene expression data from Mecp2-null and MECP2-transgenic mice
We compared gene expression changes in the hypothalamus of mice lacking MeCP2 (Mecp2-null) and mice overexpressing MeCP2 (MECP2-transgenic). Mutations in the gene encoding the transcriptional repressor methyl-CpG binding protein 2 (MeCP2) cause the neurodevelopmental disorder Rett syndrome. Loss of ...
ORGANISM(S): Mus musculus 
2008-05-30 | E-GEOD-11150 | biostudies-arrayexpress
UnknownRobust mucosal SARS-CoV-2-specific T cells effectively combat COVID-19 and establish polyfunctional resident memory in patient lungs.
Not available
S-EPMC11876067 | biostudies-literature
TranscriptomicsTranscriptional profiling of bone marrow cells of MDS patients
Myelodysplastic Syndromes (MDSs) are a heterogeneous family of clonal disorders of hematopoietic stem cells characterized by ineffective hematopoiesis and frequently leukemia progression. To exlore how MDS develop into leukemia, we performed the transcriptional profiling of lesional cells and normal...
ORGANISM(S): Homo sapiens 
2009-05-28 | E-GEOD-16236 | biostudies-arrayexpress
ProteomicsMetabolic-engineered probiotic- OMVs as nanovaccine mediating sequential immunomodulation for chronic bone infection immunotherapy
Lei et al. screen out Lactococcus lactis OMVs (Lac-OMVs) and develop metabolic-engineered NAD+-Lac-OMVs nanovaccine with potent tissue repair therapeutic effect. NAD+-Lac-OMVs sequentially activate dendritic cells by membrane component and reprogram inflammatory macrophages for anti-inflammation and...
ORGANISM(S): Mus Musculus 
2026-03-23 | PXD076052 |
ProteomicsDDX1 Methylation Mediated MATR3 Splicing Regulates Intervertebral Disc Degeneration by Initiating Chromatin Reprogramming
Low back pain (LBP), often caused by intervertebral disc degeneration (IVDD), poses a major challenge in aging populations. DDX1, an RNA-binding protein, plays key roles in RNA metabolism but its function in IVDD remains unclear. We identify DDX1 as a non-histone substrate of lysine methyltransferas...
ORGANISM(S): Homo Sapiens 
2025-05-29 | PXD064432 |
ProteomicsSARS-CoV-2 hijacks cellular kinase CDK2 to promote viral RNA synthesis
The coronavirus disease 2019 (COVID-19) pandemic has devastated global health. Identifying key host factors essential for SARS-CoV-2 RNA replication is expected to unravel cellular targets for the development of broad-spectrum antiviral drugs which have been quested for the preparedness of future vi...
ORGANISM(S): Homo Sapiens 
2022-09-28 | PXD037068 |
UnknownComparison of the Oral Calcimimetics Evocalcet and Cinacalcet in East Asian Patients on Hemodialysis with Secondary Hyperparathyroidism.
Not available
S-EPMC10658267 | biostudies-literature
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