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ProteomicsSUMOYLATION AND PROTEOTOSASIS NETWORKS CONVERGE DURING HEAT SHOCK TO MINIMIZE AGGREGATION AND PROMOTE DEGRADATION OF NUCLEAR PROTEINS
The role of stress-induced increases in SUMO2/3 conjugation during the Heat Shock Response (HSR) has remained enigmatic. We investigated SUMO signal transduction at the proteomic and functional level during the HSR in the context of cells depleted of proteostasis network components via chronic Heat ...
ORGANISM(S): Homo sapiens (Human) 
2019-03-25 | PXD010231 | Pride
Heat shock Hsf1 Small ubiquitin-like modifier Proteostasis Sumo 
ProteomicsThe SUMO protease SENP6 regulates the constitutive centromere-associated network by group
Project 1: Identification of SUMOylated proteins which are regulated by the SUMO protease SENP6. SENP6 knockdown was performed by two independent shRNAs and SUMOylated proteins were purified from U2OS expressing His10-tagged SUMO2 by means of Ni-NTA pulldown. Purified SUMOylated proteins were identi...
ORGANISM(S): Homo sapiens (Human) 
2019-09-13 | PXD011963 | Pride
Human osteosacrcoma cell line u2os Chromatin Senp6 
ProteomicsPosttranslational modifications regulate cellular responses upon UV-induced DNA damage
SUMOylation is a posttranslational protein modification which is characterized by the covalent attachment of a small 11kDa protein, called Small Ubiquitin-like MOdifier (SUMO). SUMOylation plays a pivotal role in a multitude of cellular pathways including cellular responses upon DNA damage. Here, w...
ORGANISM(S): Homo sapiens (Human) 
2019-10-11 | PXD010609 | Pride
Human Post-translational modification Sumoylation Dna damage Csb Csa 
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