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ProteomicsPeptide-mediated inhibition of the transcriptional regulator Elongin BC induces apoptosis in cancer cells
Inhibiting protein-protein interactions via designed peptides is a suitable strategy to block the function of important proteins in cells. The Elongin BC heterodimer (ELOB/C) is involved in transcription elongation and protein turnover. It interacts with target proteins via a so-called BC-box to mod...
ORGANISM(S): Homo sapiens (Human) 
2023-06-27 | PXD038414 | Pride
Peptide inhibition Elongin bc Cancer Prc2 Epop 
ProteomicsThe SAM domain-containing protein 1 (SAMD1) acts as a repressive chromatin regulator at unmethylated CpG islands
CpG-islands (CGIs) are key regulatory DNA elements at most promoters, but how they influence the chromatin status and transcription remains elusive. Here we identify and characterize SAMD1 (SAM domain-containing protein 1) as an unmethylated CGI-binding protein. SAMD1 possesses an atypical winged-he...
ORGANISM(S): Homo sapiens (Human) 
2021-05-13 | PXD016781 | Pride
Chromatin Transcription Cpg islands 
ProteomicsThe histone acetyltransferase KAT6A is recruited to unmethylated CpG islands via a DNA-binding winged helix domainThe histone acetyltransferase KAT6A is recruited to unmethylated CpG islands via a DNA-binding winged helix domain
The lysine acetyltransferase KAT6A (MOZ, MYST3) belongs to the MYST family of chromatin regulators, facilitating histone acetylation. Dysregulation of KAT6A has been implicated in developmental syndromes and the onset of acute myeloid leukemia (AML). Previous work suggests that KAT6A is recruited to...
ORGANISM(S): Homo sapiens (Human) 
2023-01-14 | PXD034833 | Pride
Winged helix Histone acetylation Cpg islands Kat6a Chromatin 
TranscriptomicsSite-specific methylation of Notch1 controls the amplitude and duration of the Notch1 response
Physiologically, Notch signal transduction plays a pivotal role in differentiation; pathologically, Notch signaling contributes to the development of cancer. Transcriptional activation of Notch target genes involves cleavage of the Notch receptor in response to ligand binding, production of the Notc...
ORGANISM(S): Mus musculus 
2015-03-26 | E-GEOD-62528 | biostudies-arrayexpress
UnknownETO, but not leukemogenic fusion protein AML1/ETO, augments RBP-Jkappa/SHARP-mediated repression of notch target genes.
Not available
S-EPMC2423149 | biostudies-literature
ProteomicsIRF2BP2 counteracts the ATF7/JDP2 heterodimer to prevent inflammatory overactivation in AML cells
Acute myeloid leukemia (AML) is a hematological malignancy characterized by the abnormal proliferation and accumulation of immature myeloid cells in the bone marrow. Inflammation plays a crucial role in AML progression, but excessive activation of inflammatory pathways can also trigger cell death. I...
ORGANISM(S): Homo sapiens (Human) 
2024-05-16 | PXD041817 | Pride
Interferon Atf7 Transcriptional regulation Irf2bp2 Jdp2 Inflammation Aml 
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