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TranscriptomicsPhenotypic, transcriptomic and genomic characterization of clonal plasma cells in light chain amyloidosis [Copy number analysis]
Immunoglobulin light-chain amyloidosis (AL) is a rare clonal plasma cell (PC) disorder that remains largely incurable. AL and multiple myeloma (MM) share the same cellular origin, but while knowledge about MM PC biology has improved significantly, the same does not apply for AL. Here, we undertook a...
ORGANISM(S): Homo sapiens 
2016-07-22 | E-GEOD-73041 | biostudies-arrayexpress
TranscriptomicsPhenotypic, transcriptomic and genomic characterization of clonal plasma cells in light chain amyloidosis [Gene expression profiling]
Immunoglobulin light-chain amyloidosis (AL) is a rare clonal plasma cell (PC) disorder that remains largely incurable. AL and multiple myeloma (MM) share the same cellular origin, but while knowledge about MM PC biology has improved significantly, the same does not apply for AL. Here, we undertook a...
ORGANISM(S): Homo sapiens 
2016-07-22 | E-GEOD-73040 | biostudies-arrayexpress
TranscriptomicsPhenotypic, transcriptomic and genomic characterization of clonal plasma cells in light chain amyloidosis
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Homo sapiens 
2016-07-22 | E-GEOD-73042 | biostudies-arrayexpress
ProteomicsConformational differences in the light chain constant domain of immunoglobulin G and free light chain may influence proteolysis in AL amyloidosis
Immunoglobulin light chain amyloidosis (AL) is a life-threatening disease caused by the deposition of monoclonal light chain (LC) and its fragments containing variable (VL) and portions of constant (CL) domains. AL patients feature either monoclonal free LCs circulating as covalent and noncovalent h...
ORGANISM(S): Homo sapiens (Human) 
2025-12-08 | PXD055570 | Pride
Igg  amyloid light chain hdx-ms  al amyloidosis  hydrogen/deuterium exchange mass spectrometry 
ProteomicsInsight into the protein composition of immunoglobulin light chain deposits of eyelid, orbital, and conjunctival amyloidosis.
Amyloidosis is a disorder characterized by the formation of extracellular amyloid deposits. Immunoglobulin light-chain amyloidosis the most common form of amyloidosis can appear as a local disorder presented with mild symptoms or as a life threatening systemic disease. Identification of the protein...
ORGANISM(S): Homo sapiens (Human) 
2014-05-29 | PXD000743 | Pride
Mass spectrometry Orbit Amyloidosis Conjunctiva Laser capture microdissection Eyelid 
UnknownLight Chain Amyloidosis: Patient Experience Survey from the Amyloidosis Research Consortium.
Not available
S-EPMC4635176 | biostudies-literature
GenomicsRNA-based full length immunoglobulin light chain sequencing reveals lambda constant domain mutations with potential implications for thermodynamic stability in light chain amyloidosis
RNA-based full length immunoglobulin light chain sequencing
PRJEB109785 | ENA
ProteomicsCryo-EM of cardiac AL-224L amyloid reveals shared features in l6 light chain fibril folds
Structural characterization of an amyloid fibril from a patient afected by cardiac light chain amyloidosis.
ORGANISM(S): Homo sapiens (Human) 
2026-01-23 | PXD064296 | Pride
ProteomicsHelical superstructures between amyloid and collagen VI in heart derived fibrils from a patient with Light Chain Amyloidosis
we investigated the N-glycosylation of the amyloid fibrils extracted from the heart of a patient affected by AL amyloidosis, using a proteomic approach to evaluate indirectly the presence of glycans in immunoglobulin light chains.
ORGANISM(S): Homo sapiens (Human) 
2024-07-02 | PXD049369 | Pride
Immunoglobulin light chains  n-glycosylation  amyloid fibrils 
UnknownIn vitro co-expression of human amyloidogenic immunoglobulin light and heavy chain proteins: a relevant cell-based model of AL amyloidosis.
Not available
S-EPMC5580339 | biostudies-literature
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