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TranscriptomicsTime course analysis of human colorectal cancer organoid treatment with Sacituzumab Govitecan (SG) or untargeted control IgG1-SN-38
Human colorectal cancer organoids were treated with the TROP2-targeting antibody-drug conjugate Sacituzumab Govitecan (SG) or non-targeting control IgG1-SN-38. Samples were harvested at different time points under treatment {0h, 3h, 6h, 9h, 12h} as well as after drug washout at 12 h on the following...
ORGANISM(S): Homo sapiens 
2026-04-01 | E-MTAB-16843 | biostudies-arrayexpress
TranscriptomicsTime course analysis of human colorectal cancer liver metastasis models under Sacituzumab Govitecan (SG) treatment or untargeted control
Human colorectal cancer organoids were injected intrasplenically to form liver metastasis in mice were treated with the TROP2-targeting antibody-drug conjugate Sacituzumab Govitecan (SG) or non-targeting control IgG1-SN-38 (ADC). Tumors were harvested at different time points: 0 h, 6 h, 24 h, 48 h,...
ORGANISM(S): Homo sapiens 
2026-04-01 | E-MTAB-16849 | biostudies-arrayexpress
TranscriptomicsSingle-cell RNA-sequencing of murine colorectal cancer tumors
Murine adenocarcinoma models VAKPS (Villin1-CreER Apc-fl/+ Kras-G12D/+ Trp5-3fl/fl Smad4-fl/fl) and VKPN (Villin1-CreER Kras-G12D/+ Trp53-fl/fl Rosa26-N1icd/+) were injected into mice to grow into subcutaneous tumors. Tumors were profiled through multiplexed single-cell RNA-sequencing.
ORGANISM(S): Mus musculus 
2026-04-01 | E-MTAB-16835 | biostudies-arrayexpress
TranscriptomicsSingle-cell RNA-sequencing of primary colorectal cancer tumor tissue and liver metastasis
Primary tumor or liver metastasis biopsies were obtained from colorectal cancer patients and processed for multiplexed single-cell RNA-sequencing.
ORGANISM(S): Homo sapiens 
2026-04-01 | E-MTAB-16583 | biostudies-arrayexpress
TranscriptomicsSingle-cell RNA-sequencing of PDOX colorectal tumors
Patient-derived colorectal cancer organoids were injected into mice to grow into subcutaneous tumors. Tumors were profiled through multiplexed single-cell RNA-sequencing.
ORGANISM(S): Homo sapiens 
2026-04-01 | E-MTAB-16585 | biostudies-arrayexpress
TranscriptomicsSingle-cell RNA-sequencing of colorectal cancer PDOX tumors treated with vehicle or the TROP2-targeting antibody-drug conjugate Sacituzumab Govitecan
Patient-derived colorectal cancer organoids were injected into mice to grow into subcutaneous tumors. Starting at 100 mm3, tumors were treated with Trodelvy (Sacituzumab Govitecan (SG)) or vehicle twice per week for 28 days before samples were harvested and subjected to single-cell RNA-sequencing of...
ORGANISM(S): Homo sapiens 
2026-04-29 | E-MTAB-16433 | biostudies-arrayexpress
TranscriptomicsTimecourse analysis of human colorectal cancer organoids under FOLFIRI chemotherapy
Two human colorectal cancer organoids derived from liver metastasis of the same patient were grown for seven days, then treated with FOLFIRI chemotherapy in vitro and sampled at different timepoints for single-cell RNA-sequencing. Time points include 0 h, 12 h, 24 h, 48 h, 72 h and 120 h on-treatmen...
ORGANISM(S): Homo sapiens 
2026-04-01 | E-MTAB-16836 | biostudies-arrayexpress
UnknownTherapeutic Anticoagulation with Heparin in Critically Ill Patients with Covid-19.
Not available
S-EPMC8362592 | biostudies-literature
UnknownTherapeutic Anticoagulation with Heparin in Noncritically Ill Patients with Covid-19.
Not available
S-EPMC8362594 | biostudies-literature
UnknownNiraparib and Abiraterone Acetate for Metastatic Castration-Resistant Prostate Cancer.
Not available
S-EPMC10431499 | biostudies-literature
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