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TranscriptomicsA high-resolution single-cell multiomic atlas of the human fetal lung - Visium
Fetal lung samples at 12–20 post conception week (pcw) from the HDBR, up to 0.5cm3 in size, were embedded in OCT and flash-frozen in dry-ice cooled isopentane. Twelve-micron cryosections were cut onto Visium slides, haematoxylin and eosin stained and imaged at 20X magnification on a Hamamatsu Nanozo...
ORGANISM(S): Homo sapiens 
2022-01-27 | E-MTAB-11265 | biostudies-arrayexpress
TranscriptomicsA high-resolution single-cell multiomic atlas of the human fetal lung - Organoid
Individual TFs were overexpressed in fetal lung tip organoids from a doxycycline-inducible construct for 3 days, and organoids were maintained in the self-renewing (tip cell-promoting) medium throughout to rigorously assay the lineage-determining competence of the TF, followed by scRNA-seq. ASCL1, ...
ORGANISM(S): Homo sapiens 
2022-01-27 | E-MTAB-11267 | biostudies-arrayexpress
TranscriptomicsA high-resolution single-cell multiomic atlas of the human fetal lung - scRNA / GEX / VDJ
We obtained human embryonic and fetal lungs from 5-22 pcw for scRNAseq and scATACseq analysis. To focus on epithelial differentiation and region specialization, we deeply sampled 15, 18, 20 and 22 pcw lungs and separated proximal and distal regions while leaving lungs at 5, 6, 9 and 11 pcw intact. T...
ORGANISM(S): Homo sapiens 
2022-01-27 | E-MTAB-11278 | biostudies-arrayexpress
ProteomicsAge-related proteomic profiling of livers from Caspase-2 deficient mice
Caspase-2 function in liver homeostasis is influenced by its important role in mitotic catastrophe to prevent survival and accumulation of aneuploid and polyploid cells. While loss of caspase-2 promotes hepatocyte polyploidy, it is unclear how this influences liver homeostasis with ageing. To addres...
ORGANISM(S): Mus musculus (Mouse) 
2025-11-20 | PXD063938 | Pride
Mus musculus Proteolytic mutation Liver Ageing Caspase-2 Polyploidy 
TranscriptomicsA high-resolution single-cell multiomic atlas of the human fetal lung - ATAC-seq
We obtained human embryonic and fetal lungs from 5-22 pcw for scRNAseq and scATACseq analysis. To focus on epithelial differentiation and region specialization, we deeply sampled 15, 18, 20 and 22 pcw lungs and separated proximal and distal regions while leaving lungs at 5, 6, 9 and 11 pcw intact. T...
ORGANISM(S): Homo sapiens 
2022-01-27 | E-MTAB-11266 | biostudies-arrayexpress
ProteomicsCaspase-2 protects against ferroptotic cell death
To identify proteins that interact with caspase-2 that could potentially explain its ability to regulate ferroptosis, we performed an unbiased BioID proteomics screen.
ORGANISM(S): Homo sapiens (Human) 
2024-03-06 | PXD041339 | Pride
Caspase-2  ferroptosis  mutant-p53  chaperone mediated autophagy 
ProteomicsFunction of the Rh5 complex in invasion of human erythrocytes
The most severe form of malaria is caused by Plasmodium falciparum. These parasites invade human erythrocytes and an essential step in this process involves the ligand PfRh5, which forms a complex with CyRPA and PfRipr (RCR complex) and binds basigin on the host cell. We identified a heteromeric dis...
ORGANISM(S): Plasmodium falciparum (isolate 3D7) 
2022-12-14 | PXD036746 | Pride
Pfripr Basigin Ptramp Human erythrocytes Invasion complex Pfrh5 Malaria Css P. falciparum 
TranscriptomicsComparison of extravillous trophoblast cells derived from human embryonic stem cells and from first trimester human placentas
The goal of the present study was to characterize HLA-G-positive cells derived from human embryonic stem cells treated with BMP4 for five days and compare them to HLA-G positive cells derived from human first trimester placentas Human embryonic stem cells were cultured with BMP4 in the absence of F...
ORGANISM(S): Homo sapiens 
2013-05-02 | E-GEOD-42112 | biostudies-arrayexpress
ProteomicsEndoplasmic Reticulum Chaperones Stabilize Ligand-Receptive MR1 molecules for Efficient Presentation of Metabolite Antigens
Quantitative MS analysis of MR1 GFP immunoprecipates to identify steady-state binding partnets.
ORGANISM(S): Homo sapiens (Human) 
2020-09-16 | PXD014585 | Pride
Mr1 Mait cells Mhc Label-free ms 
UnknownReprogramming of the esophageal squamous carcinoma epigenome by SOX2 promotes ADAR1 dependence.
Not available
S-EPMC9124436 | biostudies-literature
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