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TranscriptomicsTranscription profiling of mouse back skin during the hair growth cycle to identify hair cycle-associated genes
Identification of hair cycle-associated genes from time-course gene expression profile data by using replicate variance. Proc. Natl. Acad. Sci. USA. (2004)
ORGANISM(S): Mus musculus 
2007-11-02 | E-GEOD-1912 | biostudies-arrayexpress
TranscriptomicsDefective K-Ras Oncoproteins Initiate Cancer In Vivo and Evolve to Overcome Impaired Effector Binding
The oncogenic proteins expressed in human cancer cells are exceedingly difficult targets for drug discovery due to intrinsic properties of the Ras GTPase switch. As a result, recent efforts have largely focused on inhibiting Ras-regulated kinase effector cascades, particularly the Raf/MEK/ERK and PI...
ORGANISM(S): Mus musculus 
2011-09-30 | E-GEOD-28687 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse skins of embryos lacking Grainyhead-like epithelial transactivator (Get-1)
Defective permeability barrier is an important feature of many skin diseases and causes mortality in premature infants. To investigate the control of barrier formation, we characterized the epidermally expressed Grainyhead-like epithelial transactivator (Get-1)/Grhl3, a conserved mammalian homologue...
ORGANISM(S): Mus musculus 
2007-12-13 | E-GEOD-7381 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human MCF-7 cells with inducible LMO4 and DN-Clim expression
The nuclear LIM-only protein LMO4 is upregulated in breast cancer, especially estrogen receptor negative tumors, and its overexpression in mice leads to hyperplasia and tumor formation. Here, we show that deletion of LMO4 in the mammary glands of mice leads to impaired lobuloalveolar development due...
ORGANISM(S): Homo sapiens 
2008-11-07 | E-GEOD-7382 | biostudies-arrayexpress
ProteomicsAregger_C12ORF49_BioID_2020_TripleTOF5600
This dataset consists of 18 raw MS files and associated peak lists and result files, acquired on AB SCIEX 5600 TripleTOF mass spectrometer operated in Data Dependent Acquisition mode. Samples were generated by Michael Aregger, affinity purification and mass spectrometric acquisition was performed ...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2020-02-25 | MSV000085005 | MassIVE
ProteomicsRobust and High-Throughput Analytical Flow Proteomics Analysis of Cynomolgus Monkey and Human Matrices with Zeno SWATH Data Independent Acquisition
Modern mass spectrometers routinely allow deep proteome coverage in a single experiment. These methods are typically operated at nano and micro flow regimes, but they often lack throughput and chromatographic robustness, which is critical for large-scale studies. In this context, we have developed, ...
ORGANISM(S): Homo sapiens (Human) Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) 
2023-05-09 | PXD039414 | Pride
Dia Biofluids 7600 zenotof Tissues Zeno swath 
TranscriptomicsTranscription profiling of mouse back skin fromK14-DN-Clim
The homeostasis of both cornea and hair follicles depends on a constant supply of progeny cells produced by populations of keratin (K) 14-expressing stem cells localized in specific niches. To investigate the potential role of Co-factors of LIM domains (Clims) in such tissues, we generated transgeni...
ORGANISM(S): Mus musculus 
2008-06-16 | E-GEOD-8227 | biostudies-arrayexpress
ProteomicsIdentification of non-overlapping functions between adaptor proteins NCK1 and NCK2
Signals from cell surface receptors are often relayed via adaptor proteins. NCK1 and NCK2 are Src-Homology (SH) 2 and 3 domain adaptors that regulate processes requiring a remodelling of the actin cytoskeleton. Evidence from gene inactivation in mouse suggest that NCK1 and NCK2 are functionally redu...
ORGANISM(S): Homo sapiens (Human) 
2018-09-20 | PXD008824 | Pride
Mass spectrometry Nck adaptors Specificity 
ProteomicsTargeting of Tumor Cells by the Adenovirus E4orf4 protein via Par3 Polarity Protein-Regulated Nuclear Envelope Rupture
The protein product of the Early region 4 open reading frame 4 (E4orf4) of human adenovirus 2 is reported to exhibit a tumor-selective cell killing activity. Here, we show that E4orf4’s tumoricidal activity correlated with changes in perinuclear actomyosin contractility that are controlled by an in...
ORGANISM(S): Homo sapiens (Human) 
2020-03-19 | PXD014329 | Pride
Lamin a/c Polarity proteins Actin Live cell dynamics Nuclear bleb E4orf4 
TranscriptomicsTranscription profiling of tammar primary mammary cells challenged with E. coli-derived lipoteichoic acid or lipopolysaccharide
primary mammary cells of the tammar were cultured with 5ug/mL E. coli derived lipoteichoic acid or lipopolysaccharide for four hours. Two control groups where tammar primary mammary cells were cultured for zero and four hours without this stimulant were also used.
ORGANISM(S): Macropus eugenii 
2008-01-01 | E-TABM-350 | biostudies-arrayexpress
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