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ProteomicsQuantitative Chemical Proteomics Profiling of de novo Proteins Synthesis during Starvation-Mediated Autophagy
Autophagy is an intracellular degradation mechanism in response to nutrient starvation. Via autophagy, some non-essential cellular constituents are degraded in a lysosome-dependent manner to generate biomolecules that can be utilized for maintaining the metabolic homeostasis. Although it is known th...
ORGANISM(S): Homo sapiens (Human) 
2016-10-18 | PXD003546 | Pride
Autophagy Boncat Proteomics Aha De novo protein synthesis Itraq 
ProteomicsProteomic characterisation of the salt gland-enriched tissues of the mangrove tree species Avicennia officinalis
Plant salt glands are nature’s desalination devices that harbour potentially useful information pertaining to salt and water transport during secretion. As part of the program toward deciphering secretion mechanisms in salt glands, we adopted a shotgun approach to look into the proteome of salt-gla...
ORGANISM(S): Avicennia 
2015-07-22 | PXD000771 | Pride
Mangrove proteomics Avicennia 2dlc/ms/ms Shotgun Proteinpilot Salt gland-enriched tissues 
ProteomicsA Quantitative Chemical Proteomics Approach to Profile the Specific Cellular Targets of Andrographolide, a Promising Anticancer Agent that Suppresses Tumor Metastasis
Drug target identification is a critical step towards the understanding of the mechanism of action of a drug, which will help to improve the current therapeutic regime and to expand the drug’s therapeutic potential. However, current in vitro affinity chromatography-based and in vivo activity- based ...
ORGANISM(S): Homo sapiens (Human) 
2019-11-28 | PXD000588 | Pride
Chemical biology  drug targets*  itraq  mass spectrometry Molecular probes*   antitumor agents  metastasis 
ProteomicsHeme-activated Promiscuous Targeting of Artemisinin in Plasmodium falciparum
Plasmodium falciparum, the most pathogenic human malaria parasite, infects millions of human beings and causes a serious public health threat. Currently, the most potent anti-malarial drugs are artemisinin and its derivatives1,2. Artemisinin is a sesquiterpene lactone with an endoperoxide bridge3. T...
ORGANISM(S): Plasmodium falciparum (isolate 3D7) 
2015-12-17 | PXD002611 | Pride
Mechanism of action Target Artemisinin Chemical proteomics 
ProteomicsProteomic analysis of plasma membrane and tonoplast from the leaves of a mangrove plant Avicennia officinalis
We used gel electrophoresis coupled with LC-MS based proteomics to identify key transport proteins in the plasma membrane (PM) and tonoplast fractions of Avicennia officinalis leaves. This was part of our attempts to understand salt tolerance and secretion in mangrove plant species. PM and tonoplast...
ORGANISM(S): Avicennia 
2014-11-18 | PXD000837 | Pride
Tonoplast Plasma membrane Proteomics Avicennia officinalis Salt secretion 
ProteomicsAn optimised protocol for protein extraction from salt gland-enriched tissues of a mangrove tree species for proteomic analysis
Preparation of proteins from salt-gland-enriched tissues of mangrove plant is necessary for a systematic study of proteins involved in the plant’s unique desalination mechanism. Extraction of high-quality proteins from the leaves of mangrove tree species, however, is difficult due to the presence o...
ORGANISM(S): Avicennia officinalis 
2015-07-17 | PXD001691 | Pride
Avicennia / mangrove / protein extraction/ phenol / salt gland-enriched tissues /1d-lc-ms/ms 
UnknownNeoadjuvant Chemoradiotherapy Followed by Surgery Versus Surgery Alone for Locally Advanced Squamous Cell Carcinoma of the Esophagus (NEOCRTEC5010): A Phase III Multicenter, Randomized, Open-Label Clinical Trial.
Not available
S-EPMC6145832 | biostudies-literature
GenomicsGenome-wide Analyses of Transcription Factor GATA3-Mediated Gene Regulation in Distinct T Cell Types
We report genome-wide characterization of GATA3 binding sites in eleven well-defined developmental and effector cell types of the T lymphocyte lineage. By utilizing a conditional allele of GATA3, we investigated the impact of GATA3 expression on the mRNA expression patterns in several of these cell...
ORGANISM(S): Mus musculus 
2011-08-26 | E-GEOD-20898 | biostudies-arrayexpress
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