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ProteomicsMulticolumn Nanoflow Liquid Chromatography System with Accelerated Offline Gradient Generation for Robust and Sensitive Single-Cell Proteome Profiling
Peptide separations that combine high sensitivity, robustness, peak capacity and throughput are essential for extending bottom-up proteomics to smaller samples including single cells. To this end, we have developed a multicolumn nanoLC system with accelerated offline gradient generation. One binary ...
ORGANISM(S): Homo sapiens (Human) 
2025-05-06 | PXD049248 | Pride
High throughput Proteomics Lc-ms Storage loop Single cell proteomics Multiple columns 
ProteomicsThe cyclin dependent kinase inhibitor Roscovitine reverses diet-induced metabolic disruption in obese mice
We show that roscovitine; a cyclin-dependent kinases inhibitor; given to mice during the last six weeks of a 19-week high fat diet, reduced weight gain and prevented accompanying insulin resistance, hepatic steatosis, visceral adipose tissue (eWAT) inflammation and fibrosis. It also restored insulin...
ORGANISM(S): Mus musculus (Mouse) 
2021-11-03 | PXD027981 | Pride
Proteomics Obesity Adipose mitochondria Therapy Roscovitine 
UnknownGenetic loci and prioritization of genes for kidney function decline derived from a meta-analysis of 62 longitudinal genome-wide association studies.
Not available
S-EPMC10034922 | biostudies-literature
UnknownGenome-wide association meta-analyses and fine-mapping elucidate pathways influencing albuminuria.
Not available
S-EPMC6739370 | biostudies-literature
UnknownWhole genome sequence analyses of brain imaging measures in the Framingham Study.
Not available
S-EPMC5772158 | biostudies-literature
UnknownDifferential and shared genetic effects on kidney function between diabetic and non-diabetic individuals.
Not available
S-EPMC9192715 | biostudies-literature
UnknownBaseline Characteristics and Outcomes After Anti-Vascular Endothelial Growth Factor Therapy for Macular Edema in Participants With Hemiretinal Vein Occlusion Compared With Participants With Central Retinal Vein Occlusion: Study of Comparative Treatments for Retinal Vein Occlusion 2 (SCORE2) Report 18.
Not available
S-EPMC8949717 | biostudies-literature
UnknownIntraocular Pressure-Related Events After Anti-Vascular Endothelial Growth Factor Therapy for Macular Edema Due to Central Retinal Vein Occlusion or Hemiretinal Vein Occlusion: SCORE2 Report 16 on a Secondary Analysis of a Randomized Clinical Trial.
Not available
S-EPMC8554687 | biostudies-literature
UnknownA catalog of genetic loci associated with kidney function from analyses of a million individuals.
Not available
S-EPMC6698888 | biostudies-literature
UnknownClonal haematopoiesis and risk of chronic liver disease.
Not available
S-EPMC10405350 | biostudies-literature
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