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This project examines the proteomic impact of dysferlin deficiency using a genetically defined knock-in mouse model carrying a five-nucleotide microdeletion in the Dysf gene that corresponds to a pathogenic variant identified in limb-girdle muscular dystrophy type R2 (LGMD-R2) patients. Dysferlin is...
ORGANISM(S): Mus musculus (Mouse) 
2026-04-09 | PXD073710 | Pride
Ischemic stroke is one of the most common causes of death worldwide and a major cause of acquired disability in adults. Buyang Huanwu decoction (BHD), a traditional Chinese medicine prescription, has long been used clinically for neurological recovery after stroke. Its molecular characteristics and ...
ORGANISM(S): Mus musculus (Mouse) 
2019-02-16 | PXD006342 | Pride
Fibromyalgia (FM) is a chronic pain condition and consists of widespread pain with similarities to neuropathic pain in clinical findings, pathophysiology, and neuropharmacology. Its mechanisms are poorly understood and a lack of effective biomarkers for diagnosis and onset prediction. This study aim...
ORGANISM(S): Homo sapiens (Human) 
2022-08-12 | PXD022886 | Pride
To find out the potential targets in response to estrogen treatment on ACHN cell, a human renal cell carcinoma (RCC) cell line. Since estrogen can repress ACHN growth in a partly estrogen receptor-dependent manner, it is possible that phosphorylation state in ACHN cells is regulated.
ORGANISM(S): Homo sapiens (Human) 
2016-04-26 | PXD001962 | Pride
In this project, we generated chronic sunitinib-treated 786-O cell, a renal cell carcinoma cell line. In order to investigate the possible effect of GPR30 agonist, G-1, on the growth-inhibtion related signaling pathways, we treated either parental both parental and chronic sunitinib-treated 786-O ce...
ORGANISM(S): Homo sapiens (Human) 
2021-04-28 | PXD021254 | Pride
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