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ProteomicsLINC01021 attenuates expression and affects alternative splicing of a subset of p53-regulated genes
Loss of the p53-inducible LINC01021 in p53-proficient CRC cell lines results in increased sensitivity to DNA-damaging chemotherapeutics. Here, we comprehensively analyzed how LINC01021 affects the p53-induced transcriptional program. Using a CRISPR/Cas9-approach we deleted the p53 binding site in th...
ORGANISM(S): Homo sapiens (Human) 
2024-05-10 | PXD050892 | Pride
Purpl Linc01021 Lncrna Tumor suppression P53 
GenomicsGenome-wide characterization of effects of LINC01021 on p53-regulated gene expression in CRC cells
Genome-wide characterization of effects of LINC01021 on p53-regulated gene expression in CRC cells
PRJNA682642 | ENA
UnknownLoss of p53-inducible long non-coding RNA LINC01021 increases chemosensitivity.
Not available
S-EPMC5732690 | biostudies-literature
UnknownLINC01021 Attenuates Expression and Affects Alternative Splicing of a Subset of p53-Regulated Genes.
Not available
S-EPMC11083319 | biostudies-literature
UnknownSilencing LINC01021 inhibits gastric cancer through upregulation of KISS1 expression by blocking CDK2-dependent phosphorylation of CDX2.
Not available
S-EPMC8121629 | biostudies-literature
TranscriptomicsGenome-wide characterization of effects of LINC01021 on p53-regulated gene expression in CRC cells
We studied the effect of CRISPR/Cas9-mediated deletion of LINC01021 on genome-wide RNA expression changes after ectopic activation of p53 in CRC cells by RNA-Seq analyses
ORGANISM(S): Homo sapiens 
2024-05-15 | GSE162710 | GEO
Proteomics,Multiomicsp53-regulated networks of protein, mRNA, miRNA and lncRNA expression revealed by integrated pSILAC and NGS analyses
We determined the effect of p53 activation on de novo protein synthesis using quantitative proteomics of newly synthesized proteins (pulsed stable isotope labeling with amino acids in cell culture, pSILAC) in combination with mRNA and non-coding RNA expression analyses by next generation sequencing ...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2016-05-24 | MSV000079767 | MassIVE
Unknownp53-Regulated Networks of Protein, mRNA, miRNA, and lncRNA Expression Revealed by Integrated Pulsed Stable Isotope Labeling With Amino Acids in Cell Culture (pSILAC) and Next Generation Sequencing (NGS) Analyses.
Not available
S-EPMC4597140 | biostudies-literature
Proteomicsp53-regulated networks of protein, mRNA, miRNA and lncRNA expression revealed by integrated pSILAC and NGS analyses
We determined the effect of p53 activation on de novo protein synthesis using quantitative proteomics of newly synthesized proteins (pulsed stable isotope labeling with amino acids in cell culture, pSILAC) in combination with mRNA and non-coding RNA expression analyses by next generation sequencing ...
ORGANISM(S): Homo sapiens (Human) 
2015-07-23 | PXD001976 | Pride
Psilac Human Transcriptional network Biomarker P53 Tumor-suppressor 
UnknownIdentification of novel genetic susceptibility loci for thoracic and abdominal aortic aneurysms via genome-wide association study using the UK Biobank Cohort.
Not available
S-EPMC8409653 | biostudies-literature
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