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TranscriptomicsThe relationship between the gene expression profile in the synovium of RA patients at baseline and the clinical response to infliximab treatment
Background: Although the use of TNF inhibitors has fundamentally changed the way rheumatoid arthritis (RA) is treated, not all patients respond well. It is desirable to facilitate the identification of responding and non-responding patients prior to treatment, not only to avoid unnecessary treatment...
ORGANISM(S): Homo sapiens 
2010-04-28 | E-GEOD-21537 | biostudies-arrayexpress
UnknownAntibodies to a Citrullinated Porphyromonas gingivalis Epitope Are Increased in Early Rheumatoid Arthritis, and Can Be Produced by Gingival Tissue B Cells: Implications for a Bacterial Origin in RA Etiology.
Not available
S-EPMC9066602 | biostudies-literature
TranscriptomicsTranscription profiling of human knee synovial biopsies before and after anti-TNF treatment in patients suffering from rheumatoid arthritis
The purpose of this experiment was to do investigatge the transcriptional effect of anti-TNF treatment in patients suffering from rheumatoid arthritis. Two series of hybridizations were performed. Each hybridization was done with a technical replicate (the same amount of RNA taken from the same ampl...
ORGANISM(S): Homo sapiens 
2006-06-16 | E-TABM-104 | biostudies-arrayexpress
TranscriptomicsTranscription signature of Multiple Sclerosis in peripheral blood mononuclear cells.
Background: pregnancy is associated with reduced activity of multiple sclerosis (MS). However, the biological mechanisms underlying this pregnancy-related decrease in disease activity are poorly understood. This data series contains the subset of data used to generate a MS signature comparing female...
ORGANISM(S): Homo sapiens 
2010-01-10 | E-GEOD-17393 | biostudies-arrayexpress
TranscriptomicsPregnancy changes expression in peripheral blood mononuclear cells of healthy donors
Background: pregnancy is associated with reduced activity of multiple sclerosis (MS). However, the biological mechanisms underlying this pregnancy-related decrease in disease activity are poorly understood. This data series contains the subset of data used to generate a healthy donors signature comp...
ORGANISM(S): Homo sapiens 
2010-01-09 | E-GEOD-17409 | biostudies-arrayexpress
TranscriptomicsPregnancy changes expression in peripheral blood mononuclear cells of Multiple Sclerosis (MS) patients
Background: pregnancy is associated with reduced activity of multiple sclerosis (MS). However, the biological mechanisms underlying this pregnancy-related decrease in disease activity are poorly understood. This data series contains the subset of data used to generate a MS signature comparing female...
ORGANISM(S): Homo sapiens 
2010-01-10 | E-GEOD-17410 | biostudies-arrayexpress
UnknownThe gene expression profile in the synovium as a predictor of the clinical response to infliximab treatment in rheumatoid arthritis.
Not available
S-EPMC2892481 | biostudies-literature
TranscriptomicsTranscription profiling of rat hippocampus and cortex in the time series of Pneumococcal Meningitis infection
The aim of this work is to describe the transcriptomic changes underlying the complex mechanisms of the host response to pneumococcal meningitis in a temporal and spatial context. For this purpose we evaluated the gene expression profile of the two brain structures predominantly affected by brain da...
ORGANISM(S): Rattus norvegicus 
2010-02-24 | E-MEXP-1656 | biostudies-arrayexpress
UnknownCloning and characterization of a specific receptor for mouse oncostatin M.
Not available
S-EPMC108917 | biostudies-literature
GenomicsA Case-Controlled Study for Genotype-Phenotype Associations in Multiple Sclerosis (MS)

This is a multi-centre, case-controlled study to develop a dataset containing 1000 MS cases and 1000 matched controls and to associate DNA sequence (allelic) variations with MS phenotypes.

Study subjects were enrolled through a prospective effort initiated in 2003. Three MS clinical ce...

phs000171.v1.p1 | EGA
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