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ProteomicsHuman POT1 Prevents Severe Telomere Damage Instability Induced by Homology Directed DNA Repair
The evolutionarily conserved POT1 protein binds the single stranded G-rich telomeric DNA and has been implicated in telomeric DNA maintenance and the suppression of DNA damage checkpoint signaling. Here, we explore human POT1 function through genetics and proteomics discovering that the complete abs...
ORGANISM(S): Homo sapiens (Human) 
2020-10-21 | PXD016826 | Pride
Telomeres Affinity purification Mass spectrometry Homology-directed dna repair Tandem mass tags 
ProteomicsThe Human Telomeric Proteome During Telomere Replication
Telomere shortening can cause detrimental diseases and contribute to aging. It occurs due to the end replication problem in cells lacking telomerase. In addition, recent evidence revealed that telomere shortening can be attributed to difficulties of the semi-conservative DNA replication machinery to...
ORGANISM(S): Homo sapiens (Human) 
2021-11-03 | PXD018712 | Pride
Pot1 Telomeres Ipond Telomere fragility Histone h1 Qtip Dna replication 
ProteomicsTransformation-induced stress at telomeres is counteracted through changes in the telomeric proteome including SAMHD1
Telomeres play crucial roles during tumorigenesis inducing cellular senescence upon telomere shortening and extensive chromosome instability during telomere crisis. However, it has not been investigated if and how cellular transformation and oncogenic stress alters telomeric chromatin composition an...
ORGANISM(S): Homo sapiens (Human) 
2018-07-13 | PXD010088 | Pride
Quantitative proteomics Telomeres Samhd1 Transformation Replication stress 
UnknownSMCHD1 Promotes ATM-dependent DNA Damage Signaling and Repair of Uncapped Telomeres
Not available
S-SCDT-EMBOJ-2019-102668 | biostudies-other
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