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GenomicsDesigned, linked-domain proteins are pan-UBE2D inhibitors and induce proteostress and the unfolded protein response in HeLa cells
Designed, linked-domain proteins are pan-UBE2D inhibitors and induce proteostress and the unfolded protein response in HeLa cells
PRJNA1268535 | ENA
ProteomicsUD1long pulldown from HeLa Cell Extract
Here we used a his-tagged version of the UD1long UBE2D inhibitor to pulldown protein from HeLa cell extract
ORGANISM(S): Homo sapiens (Human) 
2025-12-11 | PXD065412 | Pride
Ube2d Ubiquitin Linked-domain inhibitors 
ProteomicsUBOX-UBL versus UBOX-UBLcontrol tranfected into HeLa Cells
In this work, we developed a suite of linked-domain UBE2D inhibitors. We transfected these constructs into HeLa cells and used shotgun proteomics with label-free quantification to measure which protein's abundances are affected by UBE2D inhibition.
ORGANISM(S): Homo sapiens (Human) 
2025-12-11 | PXD040264 | Pride
Ube2d E2 Ubiquitin 
TranscriptomicsDesigned, linked-domain proteins are pan-UBE2D inhibitors and induce proteostress and the unfolded protein response in HeLa cells
Ubiquitin (Ub) is a protein post-translational modification that controls proteostasis through mechanisms spanning transcription, translation, and protein degradation. Ub conjugation occurs through a cascade of three enzyme classes (E1, E2, and E3s) involving >1000 proteins that regulate the ubiquit...
ORGANISM(S): Homo sapiens 
2025-09-01 | GSE298221 | GEO
UnknownCharacterization of a Linked Jumonji Domain of the KDM5/JARID1 Family of Histone H3 Lysine 4 Demethylases.
Not available
S-EPMC4742734 | biostudies-literature
UnknownDesign of linked-domain protein inhibitors of UBE2D as tools to study cellular ubiquitination.
Not available
S-EPMC11398408 | biostudies-literature
UnknownRemoval of single-site N-linked glycans on factor VIII alters binding of domain-specific monoclonal antibodies.
Not available
S-EPMC8885965 | biostudies-literature
TranscriptomicsTranscription profiling of rat cirrhotic liver treated with angiogenesis inhibitors
Background and aims: There are considerable evidences demonstrating that angiogenesis and chronic inflammation are mutually dependent. However, although cirrhosis progression is characterized with a chronic hepatic inflammatory process, this connection is not sufficiently explored as a therapeutic s...
ORGANISM(S): Rattus norvegicus 
2008-06-15 | E-GEOD-6929 | biostudies-arrayexpress
UnknownNon-catalytic UBL2 domain directs deubiquitinase USP11 toward K48-linked polyubiquitin chains.
Not available
S-EPMC12718135 | biostudies-literature
UnknownConformational dynamics linked to domain closure and substrate binding explain the ERAP1 allosteric regulation mechanism.
Not available
S-EPMC8421391 | biostudies-literature
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