Sort   by:  
 Page size 
TranscriptomicsLipoic acid prevents Cr6+ induced cell transformation and the associated genomic dysregulation.
Investigation of the transcription profile of cells transformed by Cr6+ in vivo was undertaken. The objective was to elucidate genomic changes underlying the mechanism of action of the carcinogenic dose of Cr6+and their prevention using metabolic antioxidant Lipoic acid (LA). Cr6+ was administered i...
ORGANISM(S): Mus musculus 
2013-05-01 | E-GEOD-41419 | biostudies-arrayexpress
ProteomicsGlobal Profiling of Human Proteome Cysteine Residues via Lipoic Acid-Mediated Disulfide Exchange
Lipoic acid, an endogenous small molecule, is widely utilized in metabolic regulation and disease intervention. While its mechanism of action has been largely attributed to protein lipoylation, the dynamic chemical properties of its five-membered cyclic disulfide moiety remain underexplored. Here, w...
ORGANISM(S): Homo sapiens (Human) 
2026-05-23 | PXD067385 | Pride
Covalent probe Cysteine Disulfide exchange Chemoproteomics Lipoic acid 
ProteomicsGlobal Profiling of Human Proteome Cysteine Residues via Lipoic Acid-Mediated Disulfide Exchange
Lipoic acid, an endogenous small molecule, is widely utilized in metabolic regulation and disease intervention. While its mechanism of action has been largely attributed to protein lipoylation, the dynamic chemical properties of its five-membered cyclic disulfide moiety remain underexplored. Here, w...
ORGANISM(S): Homo sapiens (Human) 
2026-05-23 | PXD067411 | Pride
Covalent probe Cysteine Disulfide exchange Chemoproteomics Lipoic acid 
ProteomicsGlobal Profiling of Human Proteome Cysteine Residues via Lipoic Acid-Mediated Disulfide Exchange
Lipoic acid, an endogenous small molecule, is widely utilized in metabolic regulation and disease intervention. While its mechanism of action has been largely attributed to protein lipoylation, the dynamic chemical properties of its five-membered cyclic disulfide moiety remain underexplored. Here, w...
ORGANISM(S): Homo sapiens (Human) 
2026-05-23 | PXD067366 | Pride
Covalent probe Cysteine Disulfide exchange Chemoproteomics Lipoic acid 
ProteomicsChemoproteomic target deconvolution of Lipoic acid reveals Histone Deacetylases as the main targets
Here we set out to identify protein targets of Lipoic acid and Lipoamide by chemical proteomics approaches. We generated Lipoamide-based affinity matrices to pulldown target proteins and quantify them via bottom-up proteomics. Use of the same affinity matrix in dose dependent compeition assays allow...
ORGANISM(S): Homo sapiens (Human) 
2026-06-02 | PXD036810 | Pride
Lc-msms Drug target deconvolution Cancer cell lines 
GenomicsTranscriptomic profiling of human senescent cells in the setting of alpha-lipoic acid intervention
Transcriptomic profiling of human senescent cells in the setting of alpha-lipoic acid intervention
PRJNA657009 | ENA
Proteomicsα-Lipoic acid ameliorates consequences of copper overload by upregulating selenoproteins and decreasing redox misbalance
α-Lipoic acid (LA) is an essential cofactor for mitochondrial dehydrogenases and is required for cell growth, metabolic fuels production, and antioxidant defense. In vitro, LA binds copper (Cu) with high affinity, and as an endogenous membrane permeable metabolite could be advantageous in mitigating...
ORGANISM(S): Mus musculus (Mouse) 
2024-05-23 | PXD045233 | Pride
Α-lipoic acid Selenoprotein Copper Wilson disease Oxidative stress 
TranscriptomicsHepatic gene expression changes in aging and R-?-lipoic acid supplementation: Necroinflammatory phenotype, lipid synthesis regulation and circadian rhythms.
To determine the effects of age and lipoic acid supplementation on hepatic gene expression, we fed young (3 months) and old (24 months) male Fischer 344 rats a diet with or without 0.2% (w/w) R-?-lipoic acid (LA) for two weeks. Total RNA isolated from liver tissue was analyzed by Affymetrix microarr...
ORGANISM(S): Rattus norvegicus 
2011-03-03 | E-GEOD-27625 | biostudies-arrayexpress
TranscriptomicsTranscriptome analysis in calorie-restricted rats implicates epigenetic and post-translational mechanisms in neuroprotection and aging
Using RNA-seq, 39 cerebral cortex RNA samples were sequenced. The study design was as follows: Ad libitum fed rats at 6 months (n=3, 6 individuals pooled), 12 months (n=3, 6 individuals pooled) and 28 months (n=3, 6 individuals pooled). Calorie restricted rats at 6 months (n=3, 6 individuals poole...
ORGANISM(S): Rattus norvegicus 
2015-11-22 | E-GEOD-57110 | biostudies-arrayexpress
ProteomicsInactivation of mitochondrial pyruvate dehydrogenase by singlet oxygen involves lipoic acid oxidation, side-chain modification and structural changes
The multi-subunit pyruvate dehydrogenase complex (PDC) plays a crucial role in glucose oxidation as it determines whether pyruvate is used for mitochondrial oxidative phosphorylation, or is converted to lactate for aerobic glycolysis. PDC contains three lipoic acid groups, covalently attached at lys...
ORGANISM(S): Sus scrofa domesticus (domestic pig) 
2025-05-28 | PXD057988 | Pride
Photooxidation Lipoic acid Pyruvate dehydrogenase Glucose metabolism 
Sort   by:  
 Page size