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ProteomicsThe phosphatase activity of the PPP2R5D-PP2A holoenzyme modulates liquid-liquid phase separation of the scaffold protein liprin-α1
Liprin-α1 is a widely expressed scaffolding protein that regulates cellular processes such as cell motility and synaptic transmission through assembly of localized higher-order molecular complexes. The dynamic regulation of these complexes remains poorly understood. Liquid-liquid phase separation (L...
ORGANISM(S): Homo sapiens (Human) 
2025-06-23 | PXD063716 | Pride
Protein phosphatase 2a (pp2a)  fluorescence recovery after photobleaching (frap)  mass spectrometry (ms)  phosphorylation  liprin-α1  liprin-β1  intrinsically disordered protein domain  phase separation  houge-janssens syndrome (hjs) 
UnknownCASK stabilizes neurexin and links it to liprin-α in a neuronal activity-dependent manner.
Not available
S-EPMC4982824 | biostudies-literature
UnknownA functional interaction between liprin-α1 and B56γ regulatory subunit of protein phosphatase 2A supports tumor cell motility.
Not available
S-EPMC9519923 | biostudies-literature
UnknownLiprin-α1 is a regulator of vimentin intermediate filament network in the cancer cell adhesion machinery.
Not available
S-EPMC4830931 | biostudies-literature
UnknownRegulation of Liprin-α phase separation by CASK is disrupted by a mutation in its CaM kinase domain.
Not available
S-EPMC9500383 | biostudies-literature
UnknownLiprin-α-1 is a novel component of the murine neuromuscular junction and is involved in the organization of the postsynaptic machinery.
Not available
S-EPMC5567263 | biostudies-literature
UnknownDrosophila Syd-1, liprin-α, and protein phosphatase 2A B' subunit Wrd function in a linear pathway to prevent ectopic accumulation of synaptic materials in distal axons.
Not available
S-EPMC4061390 | biostudies-literature
ProteomicsMass spectrometry-based proteomic analysis of the liprin-α1 interactome in MIN6 cells
Accumulating evidence suggests that insulin secretion in pancreatic β cells is regulated by mechanisms analogous to synaptic vesicle release at the neuronal presynaptic active zone (AZ). Neurotransmitter release is tightly regulated in magnitude, space and time by a presynaptic macromolecular comple...
ORGANISM(S): Mus musculus (Mouse) 
2026-02-09 | PXD049219 | Pride
Presynaptic complex Pancreatic β cell Min6 Active zone Insulin exocytosis 
ProteomicsKIF1A, TANC2, liprin-a2 interactomes identified by AP-MS.
The mechanisms by which motor proteins are loaded on vesicles and how cargos are captured at appropriate sites remain unclear. To better understand how KIF1A-based transport is regulated, we identified the KIF1A interactome and focused on three binding partners, the calcium binding protein Calmoduli...
ORGANISM(S): Rattus norvegicus (Rat) 
2018-07-12 | PXD010080 | Pride
Ap-ms Tanc2 Liprin-a Lc-msms. Kif1a 
UnknownThe phosphatase activity of the PPP2R5D-PP2A holoenzyme modulates liprin-α1 liquid-liquid phase separation.
Not available
S-EPMC12273559 | biostudies-literature
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