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UnknownNatural and hybrid immunity following four COVID-19 waves: A prospective cohort study of mothers in South Africa.
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S-EPMC9481335 | biostudies-literature
ProteomicsSoluble VCAM-1 may serve as a pharmacodynamic CSF marker to monitor BACE2 activity in non-human primates
The beta-secretase beta-site APP cleaving enzyme 1 (BACE1) is a major drug target for Alzheimer’s disease (AD). Clinically tested BACE1 inhibitors induced unexpected cognitive side effects that may stem from their cross-inhibition of the homologous protease BACE2. Yet, little is known about BACE2 fu...
ORGANISM(S): Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) 
2025-07-16 | PXD056159 | Pride
Dia Cerebrospinal fluid Alzheimer's disease Csf Bace1 Macaca fascicularis Labelfree Vcam1 
TranscriptomicsExpression and regulation of lincRNAs during T cell development and differentiation
Although lincRNAs are implicated in regulating gene expression in various tissues, little is known about lincRNA transcriptomes in the T cell lineages. Here we identify 1,524 lincRNAs in 42 T cell samples from early T cell progenitors to terminally differentiated T helper subsets. Our analysis revea...
ORGANISM(S): Mus musculus 
2013-09-23 | E-GEOD-48138 | biostudies-arrayexpress
ProteomicsPlasma proteomics of BACE2 KO mice
The beta-secretase BACE1 is a central drug target for Alzheimer’s disease. Clinically tested, BACE1-directed inhibitors also block the homologous protease BACE2. Yet, little is known about physiological BACE2 substrates and functions in vivo. Here, we performed discovery proteomics to identify subst...
ORGANISM(S): Mus musculus (Mouse) 
2024-06-27 | PXD041579 | Pride
Bace2 Beta secretase Plasma Mouse 
ProteomicsPlasma proteomics of mice treated with BACE inhibitors
The Beta-secretase BACE1 is a central drug target for Alzheimer’s disease. Clinically tested, BACE1-directed inhibitors also block the homologous protease BACE2. Yet, little is known about physiological BACE2 substrates and functions in vivo. To discover potential BAC2 substrates in plasma, mice wer...
ORGANISM(S): Mus musculus (Mouse) 
2024-06-27 | PXD042669 | Pride
Bace Plasma Mus musculus 
ProteomicsPlasma proteomics of BACE1, 2, and double KO mice
The beta-secretase BACE1 is a central drug target for Alzheimer’s disease. Clinically tested, BACE1-directed inhibitors also block the homologous protease BACE2. Yet, little is known about physiological BACE2 substrates and functions in vivo. Here, we performed glycoprotein enrichment and subsequent...
ORGANISM(S): Mus musculus (Mouse) 
2024-06-27 | PXD041577 | Pride
Bace2 Glycocapture Beta secretase Plasma 
ProteomicsMicroglial proteomic signatures in APPPS1 and APP-KI mice
Microglial dysfunction is a key pathological feature of Alzheimer´s disease (AD), but little is known about proteome-wide changes in microglia during the course of AD pathogenesis and their consequences for microglial function. Here, we performed an in-depth proteomic characterization of microglia i...
ORGANISM(S): Mus musculus (Mouse) 
2020-06-09 | PXD016075 | Pride
Neuroinflammation Phagocytosis Alzheimer’s disease Proteomic signatures Microglia 
ProteomicsElenbecestat and compound 89 potently inhibit BACE1 but not BACE2 when subchronically dosed in non-human primates
The beta-secretase BACE1 (beta-site amyloid precursor (APP)-cleaving enzyme 1) is a major drug target for Alzheimer’s disease (AD), as it catalyzes the first step in amyloid beta (Abeta) generation, but has additional substrates and functions, in particular in the brain. Several advanced clinical tr...
ORGANISM(S): Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) 
2025-11-07 | PXD067461 | Pride
Proteomics Csf Bace1 inhibition Nhp Lc-ms/ms 
ProteomicsElenbecestat and compound 89 potently inhibit BACE1 but not BACE2 when subchronically dosed in non-human primates
The beta-secretase BACE1 (beta-site amyloid precursor (APP)-cleaving enzyme 1) is a major drug target for Alzheimer’s disease (AD), as it catalyzes the first step in amyloid beta (Abeta) generation, but has additional substrates and functions, in particular in the brain. Several advanced clinical tr...
ORGANISM(S): Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) 
2025-11-07 | PXD067413 | Pride
Proteomics Csf Bace1 inhibition Nhp Lc-ms/ms 
ProteomicsNeuronal differentiation of LUHMES cells is accompanied by substantial changes of the proteome
To study mechanisms of neurodegenerative diseases, neuronal cell lines are important model systems and are often differentiated into postmitotic neuron-like cells to resemble more closely primary neurons obtained from brains. One such cell line is the Lund Human Mesencephalic (LUHMES) cell line whic...
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) 
2020-09-24 | PXD020044 | Pride
Luhmes cells Dopaminergic neuron Murine midbrain neurons Parkinson’s disease 
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